# Core B: Biospecimen Core

> **NIH NIH P50** · WASHINGTON UNIVERSITY · 2024 · $253,465

## Abstract

PROJECT SUMMARY
The controlled collection and processing of clinical specimens from patients with pancreatic ductal
adenocarcinoma (PDAC) is a critical activity for an efficient and comprehensive program in translational research
in the context of a SPORE grant. Accordingly, the Biospecimen Core (Core B) has one overarching aim: We will
collect, store, process, and distribute biospecimens from patients with a diagnosis of PDAC seen at this institution
to facilitate biospecimen-based translational research: We will collect malignant cell populations from tumors
(from pre-surgical and surgical biopsies). We will also collect normal pancreas, pre-malignant pancreatic lesions,
and peripheral blood from PDAC patients. Serum and plasma will be collected for correlative and future studies.
Specimens will be collected throughout each patient's disease course (initial presentation, pre-treatment, post-
treatment/follow-up), and, where appropriate, archival specimens from previous biopsies/etc. will be retrieved.
Particular attention to specimen procurement (e.g. rapid processing of tissue to preserve transcript profiles) and
quality control will be practiced. Specimens will be processed to cellular RNA, genomic DNA, whole genome
amplified DNA, and protein extracts as required for each study. We will also collect longitudinal patient cell-free
DNA samples for downstream analysis. Cellular populations will also be viably frozen or immediately processed
for patient-derived xenograft and/or organoid creation. Importantly, we will ensure that all specimens used for
research are extensively and accurately annotated with clinical (pre-treatment, treatment, and follow-up) data
and metadata utilizing the bioinformatics infrastructure at our institution. Expert pathologic review from a
dedicated GI pathologist will ensure high-quality annotation. The aims of this Core will be accomplished by
continuing the scope of our well-established Cancer Center Tumor Bank and prior PDAC SPORE Core B
successes and an on-going, funded effort to collect solid gastrointestinal malignancies at our institution.
Specifically, Core B will expand the number of PDAC patients from whom biospecimens will be collected, and
serve as a conduit (through data and specimen sharing) to allow for a broader variety of translational research
studies in PDAC malignancies, using new and previously banked biospecimens.

## Key facts

- **NIH application ID:** 10916356
- **Project number:** 5P50CA272213-02
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Ryan C Fields
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $253,465
- **Award type:** 5
- **Project period:** 2023-08-28 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10916356

## Citation

> US National Institutes of Health, RePORTER application 10916356, Core B: Biospecimen Core (5P50CA272213-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10916356. Licensed CC0.

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