# Host-pathogen molecular and cardiovascular interaction during influenza infection

> **NIH NIH P20** · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 · $196,608

## Abstract

This study is aimed to better understand cardiovascular physiological, biomarker, and viral genomic 
heterogeneity changes from influenza infection onset to recovery during normal and differing inflammatory 
states (obesity and antiviral treatment). Thorough investigation of the spatiotemporal inflammatory 
biomarker profile along with the respiratory and cardiovascular physiological profiles from naivety to 
recovery will allow us to explore the interplay between responses to influenza infection in primary site of 
infection and its peripheral effects. The identification of novel biomarkers (molecular and proteomic) 
during an inflammatory event could significantly improve predictions for cardiovascular events. 
Additionally, more thorough genomic investigation of replicating influenza populations can lead to better 
surveillance and prediction of ongoing and emerging events. This study will investigate a major gap in 
knowledge by performing detailed analysis of cardiovascular and molecular changes associated with 
localized respiratory viral infection with obesity and antiviral treatment or chemoprophylaxis. We hope to 
modify cardiovascular events caused by respiratory virus infection (both during and after) with 
pro-inflammatory state of obese mice or reduction of inflammatory events in a timely manner with varying 
oseltamivir treatment timings. The expectation is to define markers that are present during an influenza 
virus infection that correlate with disease and changes in physiological homeostasis specifically for each 
inflammatory state (proinflammatory caused by obesity and anti-inflammatory caused by antivirals). 
Overall, we hypothesize that a localized inflammatory event in the respiratory system caused by the 
influenza virus infection leads systemic changes in normal cardiovascular physiology, biomarkers, and 
viral genomic heterogeneity that can be altered by obesity and timely admission of antiviral therapeutics.

## Key facts

- **NIH application ID:** 10917017
- **Project number:** 5P20GM144041-02
- **Recipient organization:** UNIVERSITY OF MISSISSIPPI MED CTR
- **Principal Investigator:** Brigitte Martin
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $196,608
- **Award type:** 5
- **Project period:** 2023-03-06 → 2028-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10917017

## Citation

> US National Institutes of Health, RePORTER application 10917017, Host-pathogen molecular and cardiovascular interaction during influenza infection (5P20GM144041-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10917017. Licensed CC0.

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