# Causal Mechanisms Underlying Social Pain and Suicidal Behaviors: Examining the Role of Altered Decision-making and Psychophysiological Reactivity

> **NIH NIH F32** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $22,726

## Abstract

Project Summary/Abstract
The goal of this F32 fellowship project and training plan is to prepare the candidate to independently
conduct innovative research aimed at improving our understanding of suicide risk and preventing suicidal
behaviors (SB) in high-risk populations. Despite decades of suicide risk research, our ability to predict and
prevent suicide is inadequate,24 and suicide rates continue to rise.37 Among young adults ages 18-35,
suicide is the 2nd leading cause of death.37 The proposed research is critical to understanding and reducing
suicide during the high-risk developmental period of young adulthood. Social pain and social exclusion are
theoretically and empirically associated with suicide ideation and SB, but the mechanisms by which social
pain leads to SB are largely untested. The central hypothesis is that a maladaptive response to social pain
(elicited by perceived chronic social exclusion) leads to impaired decision-making (deficits in value
comparisons) and blunted physiological reactivity (blunted sympathetic arousal and blunted
parasympathetic withdrawal), which is associated with SB. To test this hypothesis, virtual reality (VR)
simulation, a valid and safe laboratory proxy for SB, 39,50 will be used in combination with highly sensitive
objective measures of cognition and physiological arousal. These mechanisms will be examined in a
transdiagnostic sample of 125 young adults (ages 18-35) with recent suicide ideation and/or SB. This
multi-method study is a within-person crossover design, in which the sequence of the social exclusion
manipulation (exclusion vs. neutral control) is randomized across participants. Participants complete
decision-making tasks and VR suicide scenarios with physiological assessment, as well as interview and
self-report measures of suicide risk and social exclusion at pre-, post-, and 4-month follow-up. This study
has two specific aims: 1) Identify cognitive and physiological mechanisms linking social pain and
engagement in VR SB scenarios; 2) Determine the predictive value of laboratory-derived cognitive and
physiological mechanisms for future real-world SB and the potential moderators (e.g., rejection
sensitivity, perceptions of rejection) of these associations. My study will provide causal evidence for 2
modifiable mechanisms for SB: impaired decision-making and physiological arousal. This is critical to
improving our assessment, prediction, and treatment of SB. This is the fundamental step towards my
long-term goal of isolating key mechanisms in the real-world and developing effective interventions (e.g.,
attentional or cognitive bias modification,84,85 real-time biofeedback86) targeting mechanisms at critical
time points to reduce SB. With the proposed training and research plan, the candidate will develop
expertise in physiological, cognitive, and VR methodology, as well as the practical, clinical, and statistical
skills necessary to conduct cutting-edge research on suicide risk with high-ri...

## Key facts

- **NIH application ID:** 10917034
- **Project number:** 5F32MH126527-03
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Sarah Louise Brown
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $22,726
- **Award type:** 5
- **Project period:** 2022-06-01 → 2024-08-11

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10917034

## Citation

> US National Institutes of Health, RePORTER application 10917034, Causal Mechanisms Underlying Social Pain and Suicidal Behaviors: Examining the Role of Altered Decision-making and Psychophysiological Reactivity (5F32MH126527-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10917034. Licensed CC0.

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