# Translational Pathology Core

> **NIH NIH P50** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $174,691

## Abstract

PROJECT SUMMARY-ABSTRACT (Translational Pathology Core)
The overarching mission of the Translational Pathology Core is to collect human tissues associated with
clinical information and distribute to SPORE investigators to facilitate translational research. The Translational
Pathology Core will be housed and administered within the Department of Pathology to ensure
uncompromised patient care, optimal use of limited tissue resources, and patient confidentiality. The specific
goals of the core include: (1) Uncompromised patient care and proper surgical pathology diagnosis. All tissues
will be collected under IRB-approved protocols. (2) Prospective procurement of appropriate brain, breast,
pancreas and other future tissues as dictated by the needs of the SPORE projects. The core will work closely
with and enhance the existing Tissue Procurement Service of the Tissue and Molecular Pathology Shared
Resource of the University of Michigan Rogel Cancer Center. Dr. Thomas Giordano has been a director of this
shared resource continuously since 1996. (3) Expert pathology review of human tissues from surgical
pathology specimens. Dr. Sriram Venneti, a neuropathologist and accomplished glioma investigator, will review
all brain tissues, Dr. Jiaqi Shi, a GI pathologist with special expertise in pancreas cancer, will review all
pancreas tissues, and Dr. Thomas Giordano, a surgical pathologist with decades of experience in breast
pathology, will review all breast tissues. As needed, other expert pathologists from the Department of
Pathology will be recruited to support the core. (4) Tissue-based gene expression and biomarker validation
studies, such as immunohistochemistry, as indicated by the needs of the SPORE projects. Dr. Dafydd
Thomas, an expert in tissue-based investigation, will lead these efforts. Collectively, the services of the
Translational Pathology Core will support the projects by facilitating translational research and also enhance
the resources of other NCI-supported networks.

## Key facts

- **NIH application ID:** 10917045
- **Project number:** 5P50CA269022-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** THOMAS James GIORDANO
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $174,691
- **Award type:** 5
- **Project period:** 2023-08-14 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10917045

## Citation

> US National Institutes of Health, RePORTER application 10917045, Translational Pathology Core (5P50CA269022-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10917045. Licensed CC0.

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