# SNSPD-DCS at 1064 nm for non-invasive monitoring of cerebral perfusion and intracranial pressure in the ICU

> **NIH NIH U01** · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $670,370

## Abstract

Abstract
Monitoring intracranial pressure (ICP) is the global standard of care following severe brain injury. The goal of
monitoring and treating rises in ICP is to maintain adequate cerebral blood flow (CBF), thereby preventing
secondary brain injury. ICP is measured by a small pressure-sensitive probe inserted through the skull, with risk
of intracranial hemorrhage and infection, hence used only in the most critically ill patients. More importantly, ICP
probes do not directly measure CBF and critical closing pressure (CrCP), the pressure where blood flow ceases,
which is needed to correctly assess cerebral perfusion pressure (CPP). Therefore it is not currently possible to
separate benign ICP elevations from flow-limiting pressure spikes. A non-invasive monitor of ICP, CBF and CrCP
would enable targeted interventions that directly optimize cerebral perfusion and significantly expand the
potential use cases for ICP monitoring. Diffuse correlation spectroscopy (DCS) has emerged as a viable tool to
monitor CBF, CrCP and ICP. To measure CBF, DCS quantify the timescale of fluctuations in the intensity of
coherent, diffusely propagating near-infrared light, which are driven by the motion of red blood cells. DCS
measures ICP based on the morphology of the pulsatile blood flow (pCBFi) and it estimates CrCP by means of
a linear regression approach between pulsatile blood pressure and pCBFi. While successful proof of concept
studies have been conducted by our group and others, the clinical translation of DCS in adults is currently
hampered by the challenge of balancing the requirement for high brain sensitivity, which requires large source-
detector separations, and the need for high signal to noise ratio (SNR) at high acquisition rates to capture detailed
pulsatile blood flow data. Current DCS devices operate at 785 - 850 nm and are limited to separations of 2.5 cm,
offering relatively low brain sensitivity, high risk of superficial physiology contamination, and requiring pulse-
gated averages of 50-60 cardiac cycles to extract clean pCBFi signals due to limited SNR. Quantification of CBF
is strongly affected by scalp blood flow and important morphological information needed to accurately quantify
CrCP and ICP is lost during the averaging. To overcome these limitations, we propose to partner with one of the
pioneers of superconducting nanowire single photon detectors (SNSPD) technology, Quantum Opus, to develop
a compact, low sonic and thermal emission 8 channel SNSPD unit, designed with costs, manufacturability and
scalability in mind, that we will integrate with a state-of-the art 1064 nm laser system, heterodyne detection, and
fast FPGA correlator to offer bilateral DCS monitoring at 3.5 cm (>50% increase in brain sensitivity) with more
than 200-fold increase in SNR with respect to current 785 - 850 nm DCS technology. We will demonstrate the
feasibility and initial clinical utility of the SNSPD-DCS in 50 neuro-ICU patients and validate our CBF, CrCP ...

## Key facts

- **NIH application ID:** 10917051
- **Project number:** 5U01EB034228-02
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Maria Angela Franceschini
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $670,370
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10917051

## Citation

> US National Institutes of Health, RePORTER application 10917051, SNSPD-DCS at 1064 nm for non-invasive monitoring of cerebral perfusion and intracranial pressure in the ICU (5U01EB034228-02). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10917051. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*