# Systems Bioinformatics Core

> **NIH NIH U54** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $57,153

## Abstract

Systems Bioinformatics Core (Core B) SUMMARY
H-CARR is designed to interrogate the genomic, transcriptomic and metabolomic drivers of acquired cisplatin
resistance in HNSCC. Projects 1, 2 and 3 are designed to synergize with the ultimate dual objective of: 1)
identifying reliable biomarkers of cisplatin resistance and 2) developing strategies for preventing its development
or acquisition. Project 1 will generate steady state and flux metabolomic data which will be integrated with the
genomic and transcriptomic data generated in Project 2. Together, the datasets will then be validated against
human data acquired using non-invasive metabolic imaging and genomic and transcriptomic analysis of human
HNSCC circulating tumor cells (CTCs).
 Core B is envisioned as a Systems Bioinformatics Core which will coalesce the datastreams from all 3
Projects into one coherent multi ‘omics understanding of cisplatin response and development of resistance. Core
B, led by Dr. Coarfa is tasked with performing the complex data analysis proposed in each individual Project and
developing pipelines for data acquisition, analysis and interpretation which can be rapidly deployed within H-
CARR and the broader ARTNet scientific community. Core B, in collaboration with Core A (Administrative) will
develop a near real time reporting system for both model (PDX, cell line) generation, analytical pipelines and
raw and processed data sharing with other investigators. The Core will leverage existing institutional expertise
with big data analysis, along with Dr. Coarfa’s established scientific relationships with the other investigators, to
develop a state of the art analytical platform that can be deployed to characterize and understanding acquired
resistance across multiple solid tumors and systemic agents.

## Key facts

- **NIH application ID:** 10917407
- **Project number:** 5U54CA274321-03
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** CRISTIAN COARFA
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $57,153
- **Award type:** 5
- **Project period:** 2022-09-20 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10917407

## Citation

> US National Institutes of Health, RePORTER application 10917407, Systems Bioinformatics Core (5U54CA274321-03). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10917407. Licensed CC0.

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