Project Summary / Abstract The Pain Management Collaboratory Coordinating Center (PMC3) will continue to provide national leadership for the NIH-DOD-VA Pain Management Collaboratory (PMC), building on its successes over the original six-year period of funding. Three key aims are to: 1) develop, adapt, and adopt technical and policy guidelines and best practices for the effective conduct of research in partnership with healthcare systems focused on Veterans, military personnel, and their families; 2) work collaboratively with and provide technical, design, and other support to Pragmatic Clinical Trial (PCT) teams, to develop and implement a pragmatic trial protocol; and 3) disseminate widely Collaboratory-endorsed policies and best practices and lessons learned in the PCTs for implementing research within healthcare settings. Continuation of the PMC3 will permit continued support for the original eleven and two recently funded PCTs as well as PCTs to be funded via current and future requests for proposals. The PMC3 will continue to leverage the infrastructure, experience, and expertise thus far established by the Coordinating Center. Specifically, these aims will be accomplished through the highly collaborative community that comprises the PMC Steering Committee and through PMC3-managed Work Groups, a Patient Resource Group, and theme-based Discussion Groups. Essential to the continued success of the PMC is its focus on developing and sustaining strong partnerships with military Veterans and service members and with VA and DOD health care providers and organizational leaders. These partnerships ensure the meaningfulness and relevance of the research for addressing significant gaps in the management of pain and co-occurring conditions in these systems. These partnerships also help to ensure that positive PCT results and products have a high likelihood for adoption in these systems, and potentially other health care delivery systems. The proposed PMC3 continuation will support ongoing and future innovations and other successes and yield significant and impactful technical policy guidelines, best practices, and lessons learned to support the PMC and future PCTs.