# TBEL Administrative Core

> **NIH NIH U54** · JOHNS HOPKINS UNIVERSITY · 2024 · $375,071

## Abstract

Project Summary/Abstract:
The mission of the Administration Core is to ensure that the individual Research Projects, and the Research Core
combine with synergy beyond their individual parts, to contribute to the TBEL Program creating strength beyond
the individual Centers, to integrate with the NCI and the cancer research community. The Administrative Core
provides the infrastructure essential for this mission. The Core will supervise a multi-component research program
encompassing two basic science and one translational projects, and utilizing diverse data collection and analysis
modalities. To foster synergy, the Core will be the primary contact for internal activities including logistical and
organizational activities, scientific and administrative activities, and collaborative project solicitation, review,
funding, and evaluation. To embed our proposed Center within the TBEL Program and the broader cancer research
community, this Core will also be the primary contact for external interactions with the NCI, other TBEL Centers,
the Coordinating and Data Management Center (CDMC), and external cancer researchers. The Core Leaders,
Drs. De Marzo and Yegnasubramanian, have been active collaborators for 19 years, have joint funding on the NCI
SPORE grant as well as the NCI MCL grant for the past 6 years and are co-authors on 50 peer-reviewed primary
publications and 16 review articles. Drs. De Marzo and Yegnasubramanian are also embedded in internal and
external research networks that support their roles. In addition, they have co-mentored several graduate students
and post-doctoral fellows, often serving on their fellow graduate student's thesis committees. They have worked
together extensively on the molecular pathology and genomics of prostate cancer over the last 10 years, including
leading all the RNAseq and whole genomic sequencing efforts for JHU the NCI MCL-U01 projects, including the
pre-clinical atlas pilot. Also, together they have worked extensively on the molecular and cellular biology of prostate
precursor lesions , together finding partial DNA methylation of GSTP1 in high grade PIN lesions and PIA; a finding
directly relevant to the current proposal. Finally, they have worked together extensively, with Dr. Bieberich, on the
molecular pathology and genomics of mouse models of prostatic inflammation driven neoplasia and of aggressive
versus indolent prostate cancer, and with Dr. Pienta in all administrative aspects and tumor microenvironment
studies related to the NCI MCL-U01 Program.

## Key facts

- **NIH application ID:** 10918238
- **Project number:** 5U54CA274370-03
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** ANGELO Michael DE MARZO
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $375,071
- **Award type:** 5
- **Project period:** 2022-09-15 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10918238

## Citation

> US National Institutes of Health, RePORTER application 10918238, TBEL Administrative Core (5U54CA274370-03). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10918238. Licensed CC0.

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