# LEAP Administrative Core

> **NIH NIH P50** · MCLEAN HOSPITAL · 2024 · $428,360

## Abstract

Abstract
The Administrative Core for the “Laboratory in Early Psychosis” Center, a.k.a. LEAP Center, will support
continued activities of the currently existing Center. This involves the research consortium of first episode
psychosis clinics in Massachusetts and an interdisciplinary team of leading researchers. The LEAP Center is
dedicated to research in first episode psychosis, including testing an intervention strategy in our consortium of
clinics in a randomized controlled trial, extensive multimodal longitudinal data collection, and prediction and
comparative effectiveness research using various clinical datasets to better understand heterogeneity in
patient outcomes and treatment impacts. The Administrative Core will serve the Center’s goals by facilitating
regular communication, fostering synergy among disciplines, supporting training opportunities and pilot
projects, disseminating information on Center activities, organizing stakeholder panels, and overseeing
evaluation of the Center itself. The Core will be led by the Center Leads Drs. Öngür, Hsu, and Hernan, and
supported by a Center Administrator. It will be housed in dedicated office space at McLean Hospital. The Core
has four aims. First, it will oversee and coordinate all activities essential to the functioning of the Center,
including maintenance of regulatory and contractual obligations, management of budgets and subcontracts,
interacting with academic, state, and federal agencies, completion of reporting requirements, supporting
regular communication between Center elements, and fostering and tracking collaborations. Second, the Core
will oversee and coordinate governance structures including the Steering, Manuscript, Data Management and
Access, Pilot Project, and Training committees within the Center. Third, it will manage the solicitation, review,
funding, monitoring, and reporting of the conduct of an average of two R03-level pilot projects each year. And
fourth, the Administrative Core will coordinate and manage engagement with a diverse array of stakeholders
including patient and family groups, national and state policy makers, payers, as well as a panel of senior
scientific experts. The Core will also support dissemination of Center activities and advances through
conferences and short courses, visiting scholar series, clinical case conferences, as well as a website. Finally,
the Administrative Core will track objective metrics of Center performance and convene annual meetings of the
Advisory Board (composed of senior investigators within and outside of psychiatry research which will conduct
assessments of Center progress and suggest refinements). Taken together, the Core activities are designed to
ensure that the LEAP Center remains a unified whole that is greater than the sum of its parts.

## Key facts

- **NIH application ID:** 10918294
- **Project number:** 5P50MH115846-06
- **Recipient organization:** MCLEAN HOSPITAL
- **Principal Investigator:** Dost Ongur
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $428,360
- **Award type:** 5
- **Project period:** 2019-05-15 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10918294

## Citation

> US National Institutes of Health, RePORTER application 10918294, LEAP Administrative Core (5P50MH115846-06). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10918294. Licensed CC0.

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