# Integration of an opioid dispensing, monitoring, and disposal platform with a hospital pharmacy to reduce opioid use by discharged emergency department patients

> **NIH NIH R43** · ADDINEX TECHNOLOGIES, INC. · 2024 · $295,906

## Abstract

SUMMARY
The primary goal of this project is to integrate and assess the practicality of a closed-loop medication
management system dispensed through a hospital-based pharmacy with a focus on opioid pain management
for ambulatory patients with extremity fractures being discharged from the emergency department.
The Addinex system involves packaging medication in low-cost mechanical dispensers where each medication
dose requires a unique password provided by a smartphone app. The dispenser restricts medication access by
limiting each individual dose only as prescribed through unique one-time passcodes. Proper passcode entry via
dial-turning and the pull of a lever dispenses the next dose to the patient. Once patients retrieve a dose, they
are unable to access their next dose until the prescribed interval has passed, at which point they can request
the next passcode.
The system was designed to work with our partner pharmacy to deliver medication ahead of time for pre-
scheduled surgeries. However, to accommodate same-day treatment, Addinex must partner with a hospital’s
pharmacy. In addition, onboarding has heretofore been handled by a research associate. Non-study patients
must be able to on-board themselves for the Addinex platform to be an effective commercial product. This project
will adapt and enhance the system to meet these two requirements by establishing new protocols, aligning
patient management processes with emergency room workflows, streamlining onboarding procedures for both
patients and staff, and executing essential commercial steps required for successful implementation, including
the development of specific patient monitoring policies.
Collaboration with medical institutions is a crucial aspect to get the most out of the Addinex system by creating
monitoring policies tailored to various types of patients and procedures. These custom policies encompass
patient questions, notifications, alerts, and corresponding actions based on their responses. These will be
collaboratively designed in conjunction with clinical experts from Brown Emergency Department.
Once the logistical aspects of the revised system are in place, we will conduct a clinical trial involving 100 patients
with extremity fractures treated by the emergency department. Half the patients (25 adults and 25 minors) will
utilize the Addinex system, while the other half will have their opioids dispensed in a standard pill bottle as the
control group. Addinex’s system promotes the return of medication using a pre-paid disposal mailer once patients
have completed their course of treatment. The clinical study's main goals involve evaluating the system's
effectiveness with patients obtaining same day treatment. This evaluation will encompass an analysis of
medication consumption, disposal rates, pain levels, the impact of monitoring policies, and ensuring that the
established commercial protocols function seamlessly. Ultimately, the project aims to demonstrate that the
Addinex sys...

## Key facts

- **NIH application ID:** 10919085
- **Project number:** 1R43DA060717-01
- **Recipient organization:** ADDINEX TECHNOLOGIES, INC.
- **Principal Investigator:** Stanislav Roslyakov
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $295,906
- **Award type:** 1
- **Project period:** 2024-09-15 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10919085

## Citation

> US National Institutes of Health, RePORTER application 10919085, Integration of an opioid dispensing, monitoring, and disposal platform with a hospital pharmacy to reduce opioid use by discharged emergency department patients (1R43DA060717-01). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10919085. Licensed CC0.

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