Project Abstract - Overall We propose to create the Center for Innovative NeuroTech Advancement (CINTA), a new center for rapid transformation of emerging technologies into commercially viable, clinically focused solutions for disorders of the nervous system. The PD/PIs, Drs. Steven Schachter and Paolo Bonato, together have many decades of experience creating and managing complex multi-institutions, multi-disciplinary, national translational research organizations, and expertise in neurotechnology-related research, and will leverage their experience to further innovate, adapt, and deploy the well-developed, proven approach to needs-driven healthcare technology innovation pioneered, developed, and validated for 23 years by the Consortia for Improving Medicine with Innovation & Technology (CIMIT). Led for the past 23 years by Dr. Schachter and colleagues, CIMIT has a proven track record of success as a national center for healthcare innovation and a unique model to identify unmet medical needs; find, fund, and facilitate technology-based projects to solve those needs; and rapidly move these innovations from concept to manufacturing to commercialization to the end-user. Combining their decades-long expertise and interest in neurological disorders and rehabilitation, the PD/PIs will oversee the advancement of projects under CINTA’s five cores: Administrative Core, Outreach Core, Evaluation Core, Innovator Subprojects Core, and Resource Subawards Core. Paul Tessier, Program Director for the Administrative Core, will have overall responsibility for integrating the activities of the different cores to accomplish the overall goals of the proposed Center under the guidance of the Center PD/PIs. The Administrative Core will ensure ongoing input from NIH program directors and science officers, as well as input from the Steering Committee members who are integral in providing guidance to the program to help diversify the types of projects as well as increase representation of proposers of varying backgrounds. Key center activities to accomplish the overall goals include established needs assessment and project solicitation processes, and CIMIT’s virtual collaboration platform, CoLab, to help CINTA investigators and facilitators track important deliverables in four areas critical to commercial success. CoLab will also be used as a platform for shared CINTA resources, such as a CINTA website with access to resources available to key stakeholders. Finally, CINTA will draw upon the well-established national and international collaboration networks of CIMIT and Spaulding to achieve CINTA’s goals and enhance externally funded collaborations.