# Core C: Biostatistics and Bioinformatics

> **NIH NIH P50** · FRED HUTCHINSON CANCER CENTER · 2024 · $176,907

## Abstract

PROJECT SUMMARY/ABSTRACT
The Biostatistics and Bioinformatics Core will provide essential data and analytics support to investigators on
the Pacific Northwest Prostate Cancer SPORE. This Core will link study design, data collection, measurement,
and analysis to validly address critical hypotheses and questions of SPORE investigators through the following
Specific Aims.
Aim 1: Study design. Define study hypotheses, target populations, and outcomes to efficiently interrogate the
research questions of interest, reduce the chance of systematic bias, and ensure a high likelihood of detection
of biologically meaningful effects.
Aim 2: Statistical analysis. Implement quantitative methods tailored to study design and data features to
estimate effects of interest, quantify uncertainty, and provide valid inferences about the evidence supporting the
study hypotheses.
Aim 3: Bioinformatics support. Source appropriate bioinformatics tools and routines to explore biological or
mechanistic explanations for study findings and generate hypotheses for further investigation based on
molecular information from study samples.
The Biostatistics and Bioinformatics Core is integral to the collection, validation, and analysis of data for SPORE
projects. Further, where appropriate statistical methods are inadequate or lacking, Core personnel devise and
implement novel analytic approaches. The Core will provide: (1) prompt responsiveness with respect to
biostatistical and bioinformatics analyses; (2) appropriate expertise to select and implement an optimal approach
to study design and analysis; (3) customized dataset creation and analysis; and (4) clear communication of study
findings, conclusions, and limitations to investigators and the broader community.

## Key facts

- **NIH application ID:** 10919806
- **Project number:** 5P50CA097186-23
- **Recipient organization:** FRED HUTCHINSON CANCER CENTER
- **Principal Investigator:** RUTH D ETZIONI
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $176,907
- **Award type:** 5
- **Project period:** 2002-09-19 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10919806

## Citation

> US National Institutes of Health, RePORTER application 10919806, Core C: Biostatistics and Bioinformatics (5P50CA097186-23). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10919806. Licensed CC0.

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