PROJECT SUMMARY Preventable deaths in children are on the rise. Adolescent deaths by drug overdose more than doubled between 2019 and 2021 (with over 90% of deaths involving opioids), and school shootings have more than doubled in the past 5 years. The number of pediatric deaths from opioid overdose and penetrating trauma can be reduced by timely use of simple-to-use rescue tools if they are immediately accessible: naloxone is an effective antidote for opioid overdose that can restore consciousness and breathing, and tourniquets and hemostatic dressings can stem life-threatening bleeding and avert hemorrhagic shock. Whereas automated external defibrillators (AEDs) for out-of-hospital cardiac arrest (OHCA) are widespread (3 million in the US) and accessible in schools, naloxone and hemorrhage control kits rarely are publicly accessible in schools and other institutions caring for adolescents. This lack of preparedness means that preventable adolescent deaths continue to accrue unnecessarily. The AdvanceBox system publicly positions rescue tools and pairs them with technology, instructions, and links to training resources to ensure that the tools are reliably monitored, maintained, discoverable, and effectively used. The AdvanceBox cellular-connected modular storage system houses simple lifesaving tools with just-in-time rescue infographics / instructions for opioid overdose and traumatic hemorrhage, provides Web links to training videos and established learn-ahead resources, enables remote viewing and container monitoring, communicates system status, sends text/email notifications when opened, maps installations so 9-1-1 dispatchers can direct callers to nearby rescue tools, and facilitates rescue tool re-supply. In this NIH SBIR Phase I program, Nimbus Research Laboratory (NRL) will accomplish the following Aims to establish the utility and value of Design Validation Testing (DVT) prototypes and to support development of a market-ready product that can be manufactured at scale, sold, and broadly deployed: - Aim 1: Design, build, deploy, and field-test AdvanceBox Design Validation Testing (DVT) prototypes - Aim 2: Deliver just-in-time instructions and promote learn-ahead training for staff and bystander rescuers - Aim 3: Explore fit of AdvanceBox innovations with institutional needs and determine best applications The proposed SBIR Phase 1 work consists of system design, construction, and field testing with health communication and health technology consultant experts to demonstrate feasibility and utility while preparing for economic production at scale; development, packaging, and promotion of instructional and learn-ahead materials for access via AdvanceBox units; and visiting and interviewing personnel at schools and organizations that care for adolescents. NRL strives to deliver an integrated system of rescue tools, information, communications, mapping, and supply management that helps educational and youth development institutions prep...