# Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

> **NIH NIH R01** · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $1,281,984

## Abstract

Project summary
Postural orthostatic tachycardia syndrome (POTS) is a chronic disorder causing disabling symptoms and
substantial loss of productivity. Not all POTS patients are the same, and the causes and significance of different
subtypes are not known. For example, some patients may have abnormal regulation of their immune system while
others may have problems with the response of their muscles to activity. Exercise training has been shown to be a
beneficial treatment for POTS, but about 25% of patients are unable to complete the exercise program.
Our research study will examine the different types of POTS by systematically and comprehensively studying a
large diverse group of patients. This will include careful assessment of symptoms, blood tests, and heart structure
as well as a detailed analysis of the muscle response to exercise. This study will be the first to define the full picture
of different POTS subtypes and the relationship between these subtypes. Our studies will allow clinicians to better
evaluate and individualize treatment and will guide future POTS research.

## Key facts

- **NIH application ID:** 10920471
- **Project number:** 5R01HL166272-02
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** BENJAMIN D LEVINE
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,281,984
- **Award type:** 5
- **Project period:** 2023-09-15 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10920471

## Citation

> US National Institutes of Health, RePORTER application 10920471, Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS) (5R01HL166272-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10920471. Licensed CC0.

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