# A comprehensive imaging solution for dense breast cancer screening and diagnostics

> **NIH NIH R44** · MALCOVA INC · 2024 · $1,134,189

## Abstract

Project Summary
Our overarching goal in this project is the development and evaluation of a stand-alone breast cancer image
device that facilitates more rapid, effective, and definitive cancer detection and diagnosis in dense breast
women. The device being developed is based upon our proprietary Narrow-Beam Computed Tomography
(CT) technology—an image acquisition architecture that fundamentally differs from existing CT designs.
The key advantage of this technology is its ability to deliver three-dimensional images in high spatial
resolution that are nearly free of contamination from scatter, at low levels of dose deemed safe for breast
cancer screening applications, without any breast compression. The system’s unique ability to yield high
quality, fully tomographic (3-dimensional) spectral data makes possible the delivery of detailed, time-
based, diagnostic information that may allow for effective identification of malignant cancers in all women,
but specifically in women with dense breast tissue. The specific aims of this project include developing a
time-based image reconstruction to further increase the temporal resolution of the system without extending
required scan time. Validation of the developed methodology is through a hybrid 4D anthropomorphic flow
phantom developed collaboratively with our partner laboratory. Another focus of this project is gaining
insight into the clinical viability of our solution through a first in patient retrospective pilot study. Upon
completion of this project’s aims, we will have a device for large-scale in-patient prospective studies.

## Key facts

- **NIH application ID:** 10920530
- **Project number:** 2R44CA261381-02A1
- **Recipient organization:** MALCOVA INC
- **Principal Investigator:** Peymon Ghazi
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,134,189
- **Award type:** 2
- **Project period:** 2022-02-28 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10920530

## Citation

> US National Institutes of Health, RePORTER application 10920530, A comprehensive imaging solution for dense breast cancer screening and diagnostics (2R44CA261381-02A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10920530. Licensed CC0.

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