# Rapid, Automatic, AI Driven, Aortic Valve Measurement Software

> **NIH NIH R43** · DASISIMULATIONS LLC · 2024 · $443,544

## Abstract

Project Summary
While trans-catheter aortic valve replacements (TAVR) has revolutionized valve replacement, planning for this
procedure using CT imaging is a time-consuming manual process requiring hours of advanced cardiac imager’s
time. Furthermore, many centers in the United States turn over the job of measurements to in-experienced sales
reps who are more focused on the interests of the valve manufacturers they represent without any formal training
or knowledge in cardiac anatomy or physiology. DASI Simulations LLC has developed an innovative cloud-based
artificial intelligence (AI) platform that promises to automatically perform these complex measurements in a
matter of few minutes. The measurements are performed based on AI-predicted landmarks using a pipeline of
convolutional neural networks with advanced image sampling techniques. As preliminary work we have already
established the product feasibility and have our regulatory approach vetted through the FDA with a successful
presubmission completed. In this SBIR Phase 1, we propose a non-hypothesis driven approach with two specific
aims to execute on FDA recommendations to finish the verification and validation activities, namely: (1) Develop
and validate the DASI Dimensions measurement module to extract TAVR pre-planning procedural
measurements; and (2) prepare and submit document package for Food and Drug Administration (FDA) 510k
clearance. Because our technology differentiates itself from our competitors who use traditional expensive
manual measurement approaches, we are posed to make a significant positive and disruptive impact in how
structural heart therapy is planned in the clinic with potentially substantial clinical impact in terms of patient
outcomes and hospital efficiency.

## Key facts

- **NIH application ID:** 10921022
- **Project number:** 1R43HL174295-01
- **Recipient organization:** DASISIMULATIONS LLC
- **Principal Investigator:** Lakshmi Prasad Dasi
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $443,544
- **Award type:** 1
- **Project period:** 2024-08-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10921022

## Citation

> US National Institutes of Health, RePORTER application 10921022, Rapid, Automatic, AI Driven, Aortic Valve Measurement Software (1R43HL174295-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10921022. Licensed CC0.

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