# Developing Technology to Remotely Measure Molecular Composition

> **NIH NIH R43** · MSTM, LLC · 2024 · $258,586

## Abstract

There is a critical need for accurate and safe early stage detection of, e.g., infectious diseases, hazardous materials, and other
health related issues. Remote detection directly from surfaces, especially related to health concerns (in situ, in vivo) is an
underserved area of immense utility. Thus, significant commercial opportunities exist because of the dearth of these
capabilities as “demonstrated” in the current double pandemics of Covid and drugs as well as persistent threats (bacterial,
fungi, cancers, bioagents, etc.). Mass spectrometry (MS), because of its ability to detect hundreds of biological compounds
in a single acquisition provides the capability to distinguish chemical differences associated with, e.g., different pathogens
and disease states, as well as target specific compounds in or on surfaces or within compositions (e.g., drugs from Skittles),
as examples. Current MS approaches use ionization methods requiring user expertise and frequently specialized
instrumentation, which significantly increases cost. Over the past 30 years, mass spectrometers have undergone a
renaissance in their cost-to-capability ratio. For more widespread applications of MS in advancing healthcare, there is a
need for new advanced direct sampling / ion source technology that provides for minimal user intervention and long-term
use without maintenance. These attributes are necessary if testing of hundreds of individual surfaces daily per instrument to
e.g., identify, track, and contain the spread of infectious agents, or to detect cancer in biopsied tissue or cancer boundaries
during surgery is to be implemented using MS in the future. The goal of this NIH SBIR Phase I project is to demonstrate
that an entirely new sampling device-transfer-ionization approach constitutes a disruptive technology and effective method
that can be used for the next-generation disease detection and health management. The basic invention of this project is
covered by two MSTM provisional patent applications (April 3 and June 5, 2023), and earlier IP from inventors Trimpin
(CEO of MSTM) and McEwen (President of MSTM) exclusively licensed from two universities to MSTM. In summary,
these developments and remote sampling research position MSTM well for advancing this exciting area in need of new
technology. Critical advantages include exceptional ease and flexibility, on the fly results, remote sampling of 3-
dimensional surfaces without and with the use of a laser, robustness to instrument contamination and carryover, and the
capability to retrofit with commercial atmospheric pressure ionization mass spectrometers to provide accurate, safe,
detection on demand. The objective of this Phase I project is to demonstrate the feasibility and proof-of-concept of the
surface reader to sample surfaces directly with a liquid meniscus or indirectly by laser ablation. In Phase II, an FDA
approved CO2 laser will be implemented along with machine learning algorithms in a commercial product req...

## Key facts

- **NIH application ID:** 10921741
- **Project number:** 1R43GM155491-01
- **Recipient organization:** MSTM, LLC
- **Principal Investigator:** Sarah Trimpin
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $258,586
- **Award type:** 1
- **Project period:** 2024-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10921741

## Citation

> US National Institutes of Health, RePORTER application 10921741, Developing Technology to Remotely Measure Molecular Composition (1R43GM155491-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10921741. Licensed CC0.

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