# Development of a novel kit for reduction of aerosolized particles during endonasal surgeries: the PharynVac Device

> **NIH NIH R41** · PHARYNVAC SURGICAL TECHNOLOGY INC. · 2024 · $285,705

## Abstract

Project Summary
Sinonasal surgery is extremely common (>600,000 outpatient procedures annually). There are three issues
that can be mitigated with a single device: surgical staff pathogen and toxin exposure, patient blood ingestion,
and periodic obstructed endoscopic visualization. Only blood ingestion has a current solution: packing the
pharynx with absorbent materials with regular associated adverse events. Here we propose the further
development of PharynVac, a balloon aspiration catheter that simultaneously addresses all three of these
problems passively. If successful, PharynVac will decrease surgical staff exposure, reduce post-procedure
nausea, and minimize operative times, potentially becoming a standard sinonasal surgical tool. This Phase I
application would allow for the implementation of GMP (SA1), demonstrated blood and particle aspiration in a
bio-realistic oral/nasal model (SA2), and demonstrated device safety/feasibility in a large-animal sheep model
(SA3). At this point, PharynVac will move into Phase II: FDA engagement and first-in-human clinical trials.

## Key facts

- **NIH application ID:** 10922180
- **Project number:** 1R41EB035980-01
- **Recipient organization:** PHARYNVAC SURGICAL TECHNOLOGY INC.
- **Principal Investigator:** Alfred-Marc Iloreta
- **Activity code:** R41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $285,705
- **Award type:** 1
- **Project period:** 2024-09-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10922180

## Citation

> US National Institutes of Health, RePORTER application 10922180, Development of a novel kit for reduction of aerosolized particles during endonasal surgeries: the PharynVac Device (1R41EB035980-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10922180. Licensed CC0.

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