# Alcohol Research Consortium in HIV: Biostatistics and Method Core

> **NIH NIH P01** · JOHNS HOPKINS UNIVERSITY · 2024 · $209,851

## Abstract

HIV Treatment as Prevention (TASP) is critical to Ending the HIV Epidemic (EHE). At-risk alcohol use and alcohol
used disorder (AUD) are barriers to TASP through direct impacts on the HIV Care Continuum (HIV-CC). The
impact of alcohol use on other comorbidities among persons with HIV (PWH) including liver disease,
cardiovascular disease (CVD), malignancy, cognition, and frailty is increasingly relevant as persons age with
HIV. The goals of ARCH are to implement evidence based alcohol interventions across the alcohol use spectrum
(from no use, low risk, at-risk, AUD, recovery (low risk use or no use) or remission (no use) and relapse); to
understand the contextual factors (i.e., social determinants of health [SDH] from the individual to community
level) impact on alcohol use spectrum, the alcohol care continuum (Alc-CC), HIV –CC, and comorbidities; and
to determine the optimal alcohol targets (abstinence, reduction in WHO risk score) and use different sources of
alcohol measures to maximize information for determining alcohol status. The goal of the ARCH Biostatistics
and Methods Core (ARCH-BMC) is to ensure that high quality contemporary research is carried out in terms of
formulating research questions, study design, and analyses of the projects included within this P01. The ARCH-
BMC will provide expertise and leadership in epidemiology and biostatistics in the quantitative support of the
consortium. As has been done in prior years of ARCH, our group we will increase the depth to which research
questions are pursued, resulting in increased quantity, quality, and effectiveness of the consortium research
objectives, including the overall goals of the P01 (implementation science of alcohol interventions, impact of
social determinants of health, and measures of alcohol). To accomplish this goal, we propose activities for both
project support and methodological development. The specific aims of ARCH BMC are: 1) To provide wide-
ranging, high-quality epidemiological and statistical support to ARCH, 2) To provide leadership in developing
new statistical and epidemiological methods that address deficiencies in causal methods relevant to the novel
research aims of the consortium, and 3) To integrate supplemental data sources and assessment of novel
methodologies across the alcohol care continuum. ARCH-BMC adds value by contributing quantitative and
epidemiological perspectives to the ARCH P01 scientific agenda and simultaneously operationalizing the science
with appropriate study designs, data management, and analytical methodology. Successful research is
accomplished by creating comprehensive partnerships that provide expertise throughout the entire research
process, from the beginning with the conceptualization of the research question through all steps to publication.
Innovation and improved research insights are obtained when collaborations integrate novel and improved
methodology, uncovering further methodological challenges and motivating new area...

## Key facts

- **NIH application ID:** 10922745
- **Project number:** 5P01AA029544-04
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Bryan Lau
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $209,851
- **Award type:** 5
- **Project period:** 2021-09-10 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10922745

## Citation

> US National Institutes of Health, RePORTER application 10922745, Alcohol Research Consortium in HIV: Biostatistics and Method Core (5P01AA029544-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10922745. Licensed CC0.

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