# Addressing Social Needs of Adolescents and Young Adults (AYAs) with Cancer

> **NIH NIH R00** · SEATTLE CHILDREN'S HOSPITAL · 2024 · $249,000

## Abstract

PROJECT SUMMARY
Adolescents and young adults (AYAs) with cancer are at high risk for poor psychosocial and quality of life outcomes.
One way cancer may confer risk is through compromising social support, a robust predictor of psychosocial wellbeing.
AYAs highly value support from family, friends, and other AYA patients. However, many AYAs with cancer feel
isolated and report that their relationships are strained during their treatment, resulting in long term social support
deficiencies. Despite established demand, few programs targeting AYA social support needs exist. Those that do
lack theoretical bases or developmental tailoring. The current study uses a novel approach to address these
needs by adapting an evidence-based, multicomponent supportive care program to target social relationship
coping efficacy (SRCE). Defined as one’s perceived ability to maintain or enhance close relationships in the
context of illness, SRCE is a new construct with a strong theoretical basis that is well aligned with AYAs’
developmental needs. Bolstering SRCE will enable AYAs to manage cancer-related relational challenges and
seek and maintain supportive relationships, thereby buffering the negative impact of cancer on perceived
support. Moreover, targeting SRCE within the Promoting Resilience in Stress Management (PRISM) program, a
skill based AYA resilience intervention with a history of successful adaptation, will enable the success of this
work and potential for later dissemination. Building on preliminary data and following the Obesity-Related
Behavioral Intervention Trials (ORBIT) model for behavioral intervention development, the first phase of this study
(K99, 2 years) aims to refine the PRISM+SRCE adaptation. Specifically, the goals of this phase are to (1)
iteratively refine SRCE component content using AYA (n≥12) stakeholder feedback; (2) refine practical aspects
of the combined PRISM+SRCE program including delivery, training, and fidelity monitoring using AYA (n=15)
and PRISM interventionist (n=3) stakeholder feedback; and (3) develop a final intervention manual and delivery
protocol. Additionally, K99 activities will provide applied opportunities to complement the learning goals of a
promising early career behavioral scientist, including developing expertise in qualitative research methods and
training in conceptual and practical aspects of clinical trial design and conduct. The second, independent phase
of this study (R00, 3 years) aims to establish proof-of-concept of this adaptation. Through a two-site randomized-
controlled trial of N=100 AYAs newly diagnosed with cancer, the goals of this phase are to (1) establish feasibility
and acceptability of the PRISM+SRCE program; and, (2) explore whether PRISM+SRCE improves psychosocial
outcomes compared to usual care. Findings from this study will critically inform a subsequent (R01-funded)
Phase III efficacy trial of this adaptation. This project fulfills the objectives of RFA-CA-20-057 in the Cancer
Con...

## Key facts

- **NIH application ID:** 10922872
- **Project number:** 5R00CA267481-04
- **Recipient organization:** SEATTLE CHILDREN'S HOSPITAL
- **Principal Investigator:** Kaitlyn Marie Fladeboe
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $249,000
- **Award type:** 5
- **Project period:** 2022-03-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10922872

## Citation

> US National Institutes of Health, RePORTER application 10922872, Addressing Social Needs of Adolescents and Young Adults (AYAs) with Cancer (5R00CA267481-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10922872. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*