# Virtual Reality Treatment for Chronic Pain and OUD In Opioid Treatment Programs: A Randomized Controlled Trial

> **NIH NIH R01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $767,469

## Abstract

PROJECT ABSTRACT
 Over half of the 6 million persons with opioid use disorder (OUD) in the United States also suffer from
chronic pain, which reinforces a negative cycle of negative cycle of poor health outcomes and increased risk of
illicit opioid use. There is a desperate, pressing need for innovative and equitable therapies to relieve suffering
of patients with comorbid chronic pain and OUD.
 Mindfulness interventions are thought to affect pain and opioid use through directly increasing dispositional
mindfulness and by indirectly decreasing stress response, improving cognitive processing of pain (e.g., pain
acceptance), increasing positive affect, and by reducing opioid craving. Based on our group’s compelling pilot
data, we will test the hypothesis that an immersive mindfulness VR intervention will improve pain and illicit
opioid use among people with chronic pain and OUD. To do so, we will conduct a randomized controlled trial to
test the efficacy of an on-site evidence-based immersive mindfulness VR treatment (RelieVRx) vs non-
immersive VR (sham VR). We will enroll and randomize 185 participants with chronic pain and OUD to either
twice-weekly RelieVRx or twice-weekly Sham VR over 8 weeks at OTPs in the Bronx, NY, the poorest borough
in New York and a consistent epicenter for the opioid epidemic. Our co-primary outcomes are pain intensity
and illicit opioid use at 12 weeks.
 We will test the effectiveness of immersive mindfulness VR on pain and illicit opioid use in patients with
chronic pain and opioid use disorder enrolled at opioid treatment programs (Aim 1). We will examine daily
effects of the intervention on mindfulness, stress, pain, opioid craving, and physiologic stress responses (Aim
2). Lastly, we will explore mechanisms underlying intervention effects (Aim 3).
 This highly innovative project utilizes novel and emerging technology to address critical gaps in care in
vulnerable populations with comorbid chronic pain and OUD. Given our experience and expertise, our multi-
disciplinary team is well positioned to test an immersive mindfulness VR intervention in an opioid treatment
program.

## Key facts

- **NIH application ID:** 10923195
- **Project number:** 1R01DA060796-01
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Hector Ruben Perez
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $767,469
- **Award type:** 1
- **Project period:** 2024-07-01 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10923195

## Citation

> US National Institutes of Health, RePORTER application 10923195, Virtual Reality Treatment for Chronic Pain and OUD In Opioid Treatment Programs: A Randomized Controlled Trial (1R01DA060796-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10923195. Licensed CC0.

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