# Sexual Dimorphism in repair and regeneration after radiation exposure

> **NIH NIH U01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $630,543

## Abstract

ABSTRACT
This proposal aims to investigate the impact of sex as a biological variable (SABV) in the pathophysiology,
biodosimetry, and treatment of radiation injury. Current research lacks exploration of sex differences, including
the influence of gonadal hormones and sex chromosomes in hematopoietic (H-) and gastrointestinal (GI-) acute
radiation syndromes (ARS) and its long-term effects (DEARE). The study highlights the importance of
understanding these factors for gender-equitable medicine in radiation medical countermeasures. Initial data
shows increased male mortality in response to radiation, and metabolomic differences based on SABV. The
alarmin IL-33 has been shown in preliminary data and literature to exhibit sex-specific pleiotropic activation after
injury. To discern the roles of hormones and sex chromosomes, a four core genotypes (FCG) mouse model is
proposed, involving the deletion and relocation of the Sry gene. We hypothesize that SABV contributes to
radiation damage response and regeneration and sexual dimorphism in IL-33-mediated immune responses in
bone marrow and GI injury. This study will evaluate survival, histology, metabolomics, and transcriptomics in
male and female wild type mice, gonadectomized mice, FCG mice, and IL-33 modulated mice. This research will
provide insights into SABV in H-ARS and GI-ARS pathophysiology and inform potential novel therapies.

## Key facts

- **NIH application ID:** 10923561
- **Project number:** 1U01AI183947-01
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Chandan Guha
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $630,543
- **Award type:** 1
- **Project period:** 2024-06-01 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10923561

## Citation

> US National Institutes of Health, RePORTER application 10923561, Sexual Dimorphism in repair and regeneration after radiation exposure (1U01AI183947-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10923561. Licensed CC0.

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