ABSTRACT The Administrative Core will provide professional coordination and oversight to all projects and cores of this program project grant. It will ensure smooth collaborative progress toward our research goals while maintaining a high level of communication among our investigators and advisors and the National Cancer Institute, ensuring compliance with all regulations, and working together with all relevant university units as required for the timely completion of our research. Plans for organizational and administrative management, scientific and fiscal management, and coordination and communication are presented. The Specific Aims include convening and leading regular formal meetings of the investigators in this program project grant, maintaining communication among the investigators, convening meetings of the External Scientific Advisory Board and Internal Advisory Committee, reporting research results in annual Progress Reports to the NCI, processing reimbursements and other related expenses, assisting in communication among the investigators and with the NCI, compliance with all relevant university and government policies, coordination of data quality assurance, and processing of publications.