PROJECT SUMMARY/ABSTRACT The United States is facing an opioid and overdose crisis that continues to worsen, with over 100,000 American deaths last year. The COBRE on Opioids and Overdose encourages and supports junior investigators in pursuing clinical and behavioral research that explores the prevention and treatment of opioid use disorder, as well as the prevention of overdose. The COBRE is driven by the understanding that effective public health policy regarding opioids overdose requires data derived from high-quality studies like those proposed by the COBRE Junior Investigators. The goal of the Administrative Core is to support the continued successful operation of the COBRE by providing leadership and administrative support to all Investigators, Cores, and Advisory Committees. This will include oversight and prompt internal and external communication, project, fiscal and regulatory management as well as ongoing comprehensive evaluation of the entire COBRE. The Administrative Core supports the mentorship program and the growth of Research Project Leaders into independent researchers as well as the Pilot program. The Administrative Core is also responsible for promoting the thematic focus of the COBRE in all COBRE-related activities, including in the recruitment and support of Lead and Pilot Investigators. The Administrative Core is led by Dr Rich, supported by Dr Green and the Executive Committee (EC) and Advisory Committee (AC).