The primary mission of the coordinating center (CC) at the University of Pennsylvania is to facilitate the performance of immunotherapy clinical trials in dogs with cancer within the K9CIN (previously known as the Pre- medical Cancer Immunotherapy Network for Canine Trials (PRECINCT)) and to determine the suitability of dogs with spontaneous cancer to study immunomodulatory agents and combination therapies to inform human clinical trials. The CC will achieve these goals by supporting a highly coordinated clinical trials network of participating U01 sites and will work in consultation with U01 investigators, the network's Steering Committee, representatives from the Comparative Oncology Program (COP) at NCI and an External Advisory Committee to provide expert services in project management and research technology, data management, and biostatistical and bioinformatic support. Specifically, PRECINCT's CC will provide comprehensive project oversight, supervise all project management and regulatory compliance activities, and coordinate site management for all aspects of trial projects. Through the CC, U01 investigators will have ready access to research services and standard operating procedures (SOPs) for clinical and immunological monitoring and collection of data, reagents and biospecimens that will facilitate the performance of clinical research across the network. Patient accrual will be tracked and where necessary, cross-site accrual will be coordinated within the network to expedite enrollment. The CC will assist in designating supplemental funds to U01 awardees to support intra-network collaborative projects identified by a chosen scientific review panel for funding. We will continue to build infrastructure and expand the network and associate memberships will be encouraged to achieve the critical mass necessary to build working groups to advance PRECINCT's mission and build inter-network collaborations with IOTN, PI-DDN and PACMEN. We will extend PRECINCT's Data Management System to collect, store and share all clinical and correlative data amongst the U01 sites and with the COP directors and Steering Committee, through the development of a cloud-based workspace that will facilitate intra-network collaborative projects and we will perform data quality control and re-formatting required to enable ready upload to the Integrated Canine Data Commons (ICDC). We will build a specimen and reagent registry that will facilitate sharing and tracking of resources and serve to ensure their most efficient use within the network. This together with development of a cloud-based workspace, will foster collaborations between U01 researchers. We will provide biostatistical and bioinformatic support for study design and data analysis to ensure that clinical trials performed within the network are strategically designed and appropriately powered to achieve meaningful clinical and laboratory data results in the most expedite way. Together, the activities and ex...