# Drug Induced Liver Injury Network Data Coordinating Center

> **NIH NIH U01** · DUKE UNIVERSITY · 2024 · $1,654,500

## Abstract

ABSTRACT
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has proposed the continuation
of the Drug-Induced Liver Injury Network (DILIN). As described in the RFA, DILIN will be a network composed
of up to 5 Clinical Centers (CCs) with expertise in diagnosis and management of DILI and a Data Coordinating
Center (DCC) with expertise in the management of multicenter studies and clinical and translational datasets.
The major aim of the network study is to pursue genetic analyses to find predictive biomarkers as well as
genetic "fingerprints" useful for elucidating the pathogenesis of Drug-Induced Liver Injury (DILI) and ultimately
for developing specific means of prevention and or treatment. The Duke Clinical Research Institute (DCRI)
proposes to continue as the DCC for DILIN. In this role, we will apply our extensive experience and research
infrastructure to coordinate, support and facilitate the activities of the DILIN network. In particular, we will
attend to the following specific aims: (1) Support the network’s effort to increase recruitment productivity and
efficiency; (2) Support current and new DILIN studies including new mechanistic studies and/or trials; (3)
Provide overall network support of general DILIN functions; (4) Ensure quality assurance and continue data
management activities; and (5) Administer subcontracts with external partners including the analytical core at
the National Center for Natural Products Research.

## Key facts

- **NIH application ID:** 10924000
- **Project number:** 5U01DK065176-22
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Huiman X Barnhart
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,654,500
- **Award type:** 5
- **Project period:** 2003-09-30 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10924000

## Citation

> US National Institutes of Health, RePORTER application 10924000, Drug Induced Liver Injury Network Data Coordinating Center (5U01DK065176-22). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10924000. Licensed CC0.

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