# Characterizing Antiviral Washout and Viral Rebound during Analytic Treatment Interruption Studies

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $221,400

## Abstract

Project Summary/Abstract
Quantifying when antiviral activity of antiretroviral therapy (ART) or novel broadly neutralizing antibodies
(bnAbs) wane in people with HIV during treatment interruption is critical to develop therapies to cure HIV.
Further, in curative therapeutic trials, determining effects of bnAbs against virus as opposed to a potential
immune-driven “vaccinal” effect, is essential to evaluating long-lasting post treatment efficacy. Here we
propose to leverage existing data and technologies to quantify ART in plasma, cells in circulating blood, and
tissue from an observation ART interruption study, to quantify how waning levels of ART alone are related to
viral rebound and changes in reservoirs in the same samples (Aim 1). Then, we will quantify antiviral activity of
bnAbs in human tonsil tissue cells and use this to inform the relative contribution of antiviral activity as
opposed to another immune-mediated effect during a clinical intervention study using the same bnAb (Aim 2).
These aims will provide essential knowledge surrounding viral rebound during ART interruption including
optimal timing to assess therapeutic efficacy and determine if the postulated “vaccinal” effects of bnAbs exist.
This work with inform design of future clinical trials for HIV cure but will also have broad implications for HIV
treatment and prevention.

## Key facts

- **NIH application ID:** 10924686
- **Project number:** 1R21AI184166-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Amelia N Deitchman
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $221,400
- **Award type:** 1
- **Project period:** 2024-07-24 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10924686

## Citation

> US National Institutes of Health, RePORTER application 10924686, Characterizing Antiviral Washout and Viral Rebound during Analytic Treatment Interruption Studies (1R21AI184166-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10924686. Licensed CC0.

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