Program Summary-Overall Indian Health Council, Inc. (IHC) with San Diego State University (SDSU) and University of California San Diego (UCSD), intends to build upon their already existing long-term research partnership in the proposed projects/studies in the NARCH X application. The Student Development Program will further expand and refine strategies to recruit students from local academic institutions into biomedical and behavioral sciences as well as, continue to provide strong mentorship and guidance for the students in and outside of the region. American Indian and Alaska Native (AI/AN) students are the least likely of any minoritized group to complete a bachelor’s degree and bachelors, masters, and doctoral degree attainment has remained the same or decreased since 2000 in both STEM and non-STEM fields. This is despite AI/AN communities facing some of the largest disparities in health outcomes, thus justifying a critical need to train more AI/AN health scientists to improve health equity. The CA-NARCH SDP was established in 2003 and is a partnership between Indian Health Council (IHC), serving 9 regional tribes, and the academic partners of San Diego State University (SDSU), University of California San Diego (UCSD), California Sate University- San Marcos (CSUSM), and Palomar Community College (PCC). The CA-NARCH SDP has significantly addressed gaps in AI/AN academic achievement and has supported 135 students, with 97% being retained in their STEM programs over its 17 year history. Thus far, 10 students have received a PhD, with 18 additional students currently in PhD programs. 28 students have completed masters degrees, and 15 are currently in masters programs. Students are dedicated to working in Indian County and 17 students currently have full time positions in Indian Country; Two students have thus far become faculty members at 4 year universities. The aims of the CA-NARCH SDP include: 1) Identify and recruit AI/AN students in the biomedical and behavioral sciences from community college through graduate school into the CA-NARCH SDP program; 2) Retain AI/AN students in their respective higher education programs and develop and enhance their knowledge, skills, science-self efficacy, and persistence to succeed in STEM programs to successfully matriculate into graduate programs; 3) Engage and provide training for AI/AN students in biomedical and health research to increase their competitiveness for jobs/graduate school and their likelihood of becoming health/science researchers; 4) Increase the cultural interface and competencies of the CA-NARCH students and encourage AI/AN community engagement and trust in research. Centered at IHC, the CA-NARCH SDP has established infrastructure with a SDP team, including a full-time native coordinator (Luiseño), and an established presence and leads on the 4 surrounding campuses. Students are recruited from the 4 campuses, AI/AN organizations, faculty directors of NIH and NSD funded science enrichment...