# Core C: Neuropathology Core

> **NIH NIH P01** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $28,121

## Abstract

ABSTRACT
An integrated approach to Neuropathology is a central element of all studies detailed in the four projects.
Focusing neuropathological aspects of this Program in a core facility allows closer coordination of the efforts of
the Program’s investigators and provides an interface between the Program and key laboratories: Anatomic
Pathology, Clinical / Research Neuropathology, and the VHC. Aside from the obvious benefits that a
Neuropathology Core can provide in terms of concerted experimental design / planning and that come with a
centralized and uniform approach to the processing and assaying of tissues, a Core can facilitate adherence to
regulatory issues relating to the accessioning and processing of human and animal tissues for research, can
produce financial benefits through efficient use of manpower and reagents, and can simplify and secure data
recording and presentation.
Core C pathologists are strategically placed to take advantage of the material they will review, comparing
morphological and immunophenotypic variation in human and mouse CNS tumors in the context of a wealth of
genetic data generated over the Program’s last budget cycle [2-4, 27-33]. The two Core C pathologists have an
interest in the analysis of CNS tumors and proven expertise in this area, as reflected by their publications (see
later in this section and biosketches).
Together with the other project leaders, our Program team has the potential to capitalize on their findings by
producing novel enhancements to the molecular classification of medulloblastomas and pediatric high-grade
gliomas and potentially to lay the foundations for an integrated pathological and molecular approach to the
diagnosis of pediatric CNS tumors, utilizing a combination of detailed histopathological evaluation and novel
molecular markers to classify tumors for the purpose of therapeutic stratification or as suitable for novel targeted
therapies.

## Key facts

- **NIH application ID:** 10925211
- **Project number:** 5P01CA096832-19
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **Principal Investigator:** Brent Alan Orr
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $28,121
- **Award type:** 5
- **Project period:** 2003-04-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10925211

## Citation

> US National Institutes of Health, RePORTER application 10925211, Core C: Neuropathology Core (5P01CA096832-19). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10925211. Licensed CC0.

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