PROJECT SUMMARY/ABSTRACT – CORE A The HCC OvCa SPORE Administrative Core (Core A) is co-directed by SPORE PIs Ronald Buckanovich, MD, PhD and Robert Edwards, MD. Core A will (i) provide scientific, fiscal, and general administrative oversight to all SPORE components, (ii) work to facilitate the research productivity of the three SPORE Projects, (iii) expand the utility and efficiency of the SPORE’s two Shared Resource Cores, and (iv) ensure the success of the Career Enhancement Program (CEP) and Developmental Research Program (DRP) to generate a pipeline of new OvCa investigators and projects. To ensure the success of the SPORE, Core A will coordinate sharing of SPORE data as well as internal and external communications and interactions. This includes coordinating agreements with collaborating institutions and community outreach with patient advocates. Core A will convene monthly meetings attended by all SPORE Investigators, coordinate periodic administrative and scientific reviews, release and publicize RFAs and arrange for the review of received CEP and DRP applications, and work closely with the NCI Translational Research Program Office. It will provide the administrative framework through which the SPORE Executive Committee, Internal Advisory Board (IAB), and External Advisory Board (EAB) can evaluate program activities and will redirect resources, as appropriate, to maximize progress toward the SPORE’s translational goals. Core A will monitor the budgets of the individual SPORE, CEP, and DRP Projects and Cores to ensure that no duplication of effort occurs between the SPORE and institutional shared resources, national consortia or cooperative groups, or other funded research grants. The Core will also ensure that the SPORE’s research activities are conducted in compliance with all local and federal regulations and guidelines, including those for protecting the safety and personal health information of patients. Core A will benefit from the effort of a qualified SPORE Administrator who assists in scheduling and in preparing reports and manuscripts. Impact: Through Core A functions, the SPORE as a whole will benefit from the centralization of essential services, and each SPORE component will be afforded the opportunity to maximize the effort devoted to research and patient-oriented advances in ovarian cancer.