Project Summary: The CEC Core of the Colorado SCORE program is focused on providing career enhancement for researchers in the innovative, growing field of sex differences research. The Objectives of the CEC Core are 1) To develop and support a cadre of accomplished early career researchers in the thematic focus of the SCORE, Bioenergetic and Cardiometabolic Consequences of the Loss of Gonadal Function, and 2) To provide a curriculum that meets the career enhancement needs of the early career faculty scientists focused on translational science in the study of sex differences. Objective 1 will be carried out by selecting a SCORE Scholar through peer review who will be focused on developing a career in sex differences research. The SCORE Scholar will have salary support to cover at least 75% of their time as well as project support. In addition, relevant pilot projects will be awarded (by peer review) to four promising scientists per year. For Objective 2, SCORE Scholars and Pilot Awardees will participate in an innovative career enhancement program including team mentoring, hands-on research experience and curricular training in academic skills, career development skills and methods by which to study sex differences from the Ludeman Family Center for Women’s Health Research (Ludeman Center) as well as a weekly works in progress session run by the Investigations in Metabolism, Aging, Gender, and Exercise (IMAGE) group of the Multidisciplinary Center on Aging (home of the SCORE). In addition, trainees will receive training in relevant topics in endocrinology. SCORE Scholars and Pilot Awardees will receive curricular training along with the Scholars in the Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) K12, Colorado Clinical & Translational Sciences Institute (CCTSI) and the Ludeman Center. These trainings will be provided by the Ludeman Center. Dr. Regensteiner, proposed CORE Leader, is the Director of the Ludeman Center as well as PI of the BIRCWH grant and has led the development of the academic skills and career development skills curricula that will be utilized in the proposed SCORE. The mentoring, research experience and curricular training provided by this program will help the SCORE Scholar and Pilot Awardees develop careers in the growing area of sex differences research. Developing the workforce in this area is critical to the field becoming fully realized. Success in this endeavor means that health and disease in women and men will be optimally studied so that medical research benefits everyone to the highest level possible.