Core A: Administrative Core Abstract The administrative core is designed to coordinate and support all the activities of this Program. It will work pro-actively to assure complete integrations across the Research Projects and Cores around the theme of “integrative genomics” that is the focus of the program. The Core will be responsible for overseeing the day-to-day activities of this program and assuring that the overall goals of the program are achieved. Among other activities, this Core will organize biweekly meetings of the entire research team, coordinate scientific seminars and workshops, and hold an annual retreat. We have assembled an External Advisory Committee (EAC) comprising experts from outside USC in statistical genetics, cancer genetic epidemiology, integrative genomics, bioinformatics, and high-performance computing. We have also assembled an Internal Advisory Committee (IAC) drawing on the deep expertise of our colleagues across these same disciplines within USC. The Core will coordinate an annual meeting of the EAC and quarterly meetings of the IAC, and it will facilitate additional interactions with EAC or IAC members throughout the year as needed. The Core will coordinate travel, purchase supplies, monitor budgets, handle personnel issues, submit annual progress reports, and facilitate recruitment of new investigators, post docs, and students. As co-directors of this core, Drs. Gauderman and Siegmund will jointly assume responsibility for all organizational and financial activities of the project. In addition, Dr. Gauderman will assume specific leadership of Project activities and Dr. Siegmund specific leadership of Core activities. These Project- and Core-specific roles will guarantee that both important elements of the overall program are being adequately administered. They will also establish the infrastructure needed for effective communications and collaboration across the Projects and Cores. They will co-chair our IAC and plan one annual meeting of the EAC as well as a separate annual scientific retreat with all program and core investigators. Leveraging their experience as Director of the Division of Biostatistics (Dr. Gauderman) and Director of our Biostatistics and Epidemiology Education Program (Dr. Siegmund), they will assure that the ambitious goals of this program are fully coordinated and supported.