# Cancer Metabolism Core

> **NIH NIH U54** · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $89,060

## Abstract

METABOLISM CORE
Abstract
The metabolism core of the proposed the UNMC Acquired Resistance to Therapy Network (ARTNet) Center for
Pancreatic Cancer (ACPC) will study innovative, hypothesis-driven mechanisms of metabolic and signaling
alterations that contribute to acquired therapy resistance in pancreatic ductal adenocarcinoma (PDAC). The core
services provided by the metabolism core will be well integrated into all the three projects. The core will offer
cost-effective metabolomics and data analysis support with appropriate quality controls for all projects by
providing a centralized infrastructure and expertise in metabolomics, physiological assays, and metabolic
dependency/vulnerability screens. The metabolism core will have three specific aims. The basic capabilities
offered by the Core will include steady-state polar metabolomics and lipidomics (Specific Aim 1), Stable Isotope
Resolved Metabolomics (SIRM) with kinetic flux analysis (Specific Aim 2), and Seahorse extracellular flux
analyzer-based assays, fluorescent assays to investigate the metabolic state of cells, and identifying metabolic
vulnerabilities (Specific Aim 3). The Metabolism Core will participate in the design and conduct of steady-state
polar metabolomics, lipidomics, 13C-metabolite labeled kinetic flux analysis with cell lines, organoids, and
exosomes. The core will also perform steady-state polar metabolomics and lipidomics for mouse and human
tumor tissue specimens in all the projects. The core will also provide hands-on training, as needed, for the ACPC,
other ARTNet centers, and other investigators. The core will also provide support for measuring drug
concentrations and metabolism in the tissues and drug pharmacokinetics/ pharmacodynamics studies.

## Key facts

- **NIH application ID:** 10926944
- **Project number:** 5U54CA274329-03
- **Recipient organization:** UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- **Principal Investigator:** Pankaj Kumar Singh
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $89,060
- **Award type:** 5
- **Project period:** 2022-09-20 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10926944

## Citation

> US National Institutes of Health, RePORTER application 10926944, Cancer Metabolism Core (5U54CA274329-03). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10926944. Licensed CC0.

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