PROJECT SUMMARY/ABSTRACT: PRAGMATIC IMPLEMENTATION SCIENCE METHODS (PrISM) CORE Regardless of their research training or inherent talent, the learning curve for new investigators in implementation science can be steep. The PrISM Core will provide COBRE and other KUMC investigators the coordinated, interdisciplinary support that is critical to success in this complex field. PrISM’s ‘team science’ approach will increase the likelihood of successful execution of research projects and better prepare Project Leads for working in the collaborative research environment that is critical to implementation science. Aim 1. Establish an Implementation Science methods Core bringing together expertise in implementation science theory and methods and leveraging the principles of team science to seamlessly integrate expertise in biostatistics, medical informatics, mixed methods research, and health equity research. The PrISM Core will work closely with the CEO core to provide researchers with access to research sites and clinical data needed to support pragmatic implementation research that advances health equity. Aim 2. Support COBRE Project Leads in project conceptualization, design, execution, and analysis, and plans for future research. We will use an adaptation of Proctor’s classic model of implementation research to create a framework for supporting Project Leads through each step of equity-focused implementation research, including: describing existing disparities in treatment, developing implementation strategies, analyzing outcomes, reporting results, and designing new, innovative research proposals to extend or disseminate findings from COBRE-supported work. Aim 3. Foster new applications and implementation science methods to address health equity. PrISM will work with the Administrative Core to identify and support new investigators and advance implementation science methods, including methods that address unique issues in rural, minority and other underserved communities. PrISM will also continually scan the field to identify critical gaps in equity-focused implementation research in order to help prioritize COBRE efforts. Aim 4. Collaborate with the Administrative Core to evaluate PrISM performance. The PrISM core addresses a previously unmet need at the University of Kansas Medical Center for an integrated team focused on implementation science. The PrISM Core will increase institutional and regional capacity to conduct high quality implementation research, will make research projects more pragmatic, and as a result will increase the COBRE’s potential for sustained and widespread impact on the field.