# Project 2: The cell types and states of painful neuromas

> **NIH NIH U19** · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $449,370

## Abstract

PROJECT SUMMARY (Project 2)
We propose a plan for the development of a biobank of human neuroma and intact nerve tissues,
accompanied by a comprehensive set of transcriptomic, proteomic, and histological analyses, to generate
correlations and testable hypotheses on the mechanistic basis for the pain in painful neuromas and the active
biochemical and signaling pathways that may contribute to this phenotype that will be an important tool for the
pain community to identify the exact composition and spatial architecture of painful neuromas and the
identification of those features that uniquely are present only in the presence of pain.
Given that painful neuromas are a major source of peripheral neuropathic pain, and that recent data
increasingly points to immune and glial cells as drivers of the pain by virtue of the signaling molecules that they
produce to act on injured neurons, the data generated may realistically provide important and novel insight into
the pathophysiology of neuropathic pain in patients which in turn could lead to the development of new
therapeutic strategies. It is conceivable that the data may reveal that the drivers of pain may change with time
and may be linked to the genotype of patients or coexisting diseases, features which preclinical studies will not
reveal.

## Key facts

- **NIH application ID:** 10928099
- **Project number:** 5U19NS130617-03
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** CLIFFORD J WOOLF
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $449,370
- **Award type:** 5
- **Project period:** 2022-09-19 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10928099

## Citation

> US National Institutes of Health, RePORTER application 10928099, Project 2: The cell types and states of painful neuromas (5U19NS130617-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10928099. Licensed CC0.

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