# Washington University Omics Production Center

> **NIH NIH U01** · WASHINGTON UNIVERSITY · 2024 · $4,073,534

## Abstract

Project Summary
To improve our understanding of human disease in ancestrally diverse populations, we propose to establish
the Washington University Omics Production Center (WU-omics PC). As part of the Multi-Omics of Health and
Disease Consortium, the WU-omics PC will help design a collaborative plan to: (i) explore the use of multi-
omics, environmental exposure data, and phenotypic information to assess disease states; (ii) develop
methods for data harmonization, integration, and interpretation in multi-omics studies; and (iii) create a rich set
of robust multi-dimensional data to share with the research community. In the first year of the award, the WU-
omics PC will work closely with other members of the Consortium to design a project roadmap that details
strategies for subject recruitment, the types of biospecimens to be collected, sample handling and shipping
procedures, omics techniques to be performed, and best practices for transferring and integrating harmonized
data. After year 1, we propose for the WU-omics PC to collect whole genome sequencing, whole genome
bisulfite sequencing, ATAC-seq, RNA-seq, proteomics, and metabolomics data by using the agreed upon
methods. The WU-omics PC will collect omics data by using well-established workflows that the same
investigative team has already successfully applied to other multi-omics studies of similar scope and scale. Our
omics workflows have been extensively benchmarked and we have detailed protocols for quality assurance,
quality control, and correction of batch effects. The WU-omics PC is uniquely positioned to accomplish its
goals because the infrastructure to perform large-scale, high-throughput omics assays is already in place.
Moreover, the leadership of the WU-omics PC has a successful track record of participating in omics consortia
and provides complementary and synergistic research expertise in genetics, biochemistry, analytical
instrumentation, computational data processing, and multi-dimensional data integration.

## Key facts

- **NIH application ID:** 10928203
- **Project number:** 5U01HG013227-02
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Gary J Patti
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $4,073,534
- **Award type:** 5
- **Project period:** 2023-09-12 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10928203

## Citation

> US National Institutes of Health, RePORTER application 10928203, Washington University Omics Production Center (5U01HG013227-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10928203. Licensed CC0.

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