# Genome Editing and Biological Effects Testing: Somatic Cell Gene Editing Testing

> **NIH NIH U42** · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $810,421

## Abstract

PROJECT SUMMARY: GENOME EDITING TESTING SECTION
This project addresses an unmet need for essential services related somatic cell genome editing. This
project will provide models that recapitulate human conditions and harbor human target sequences.
Further, this project will provide testing services to evaluate safety and efficacy of potential therapeutic
strategies. The Coordination Section provides for central management, coordination, and communication
for the Resource and Testing Sections. This core ensures that data will be preserved and appropriately
communicated. These responsibilities also include communication with Center Users, the Program
Steering Committees, and various collaborators. The Resource Section will be to produce, import,
cryopreserve, validate, and supply unique swine models for testing somatic cell genome editing reagents.
The Resource Section will maintain breeding colonies and produce cohorts of experimental animals. These
novel swine models will provide unique opportunities to translate basic science to clinical applications. The
Testing Section will be responsible for creating, refining, and performing detailed standard operating
procedures (SOPs) and comprehensive reports for testing new genome editing technologies. This section
will provide for robust, standardized, and comprehensive analysis of potential therapies in large animals to
facilitate in translation of basic research into clinical applications.

## Key facts

- **NIH application ID:** 10928245
- **Project number:** 5U42OD035738-02
- **Recipient organization:** UNIVERSITY OF MISSOURI-COLUMBIA
- **Principal Investigator:** JONATHAN A GREEN
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $810,421
- **Award type:** 5
- **Project period:** 2023-09-12 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10928245

## Citation

> US National Institutes of Health, RePORTER application 10928245, Genome Editing and Biological Effects Testing: Somatic Cell Gene Editing Testing (5U42OD035738-02). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10928245. Licensed CC0.

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