# Resource: Swine Somatic Cell Gene Editing Testing Center

> **NIH NIH U42** · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $270,601

## Abstract

PROJECT SUMMARY: RESOURCE SECTION
The role of the Genome Editing Resource Section will be to produce, import, cryopreserve, validate, and
supply unique swine models. These models will serve as specialized tools to evaluate novel reagents
(Reporter models) as well as serving as models for human conditions (Disease models). The disease models
will provide for fully-human target alleles to evaluate gene editing but will also recapitulate the human condition
to evaluate therapeutic value, alleviation of symptoms, and therapeutic windows of opportunity. Additionally,
the Resource Section will be responsible for procurement or production of animals and surveillance of
biosecurity. The Resource Section will maintain breeding colonies and produce cohorts of experimental
animals. Further, the Resource Section will be responsible for assembly and maintenance of BSL2 facilities for
use by the Testing Section. Our group is ideally suited to provide this testing due to our unique composition of
individuals that are experienced with pig production, swine biomedical models, operate successful labs that
routinely test cutting-edge genome editing technology, and are associated with world-renowned National Swine
Resource and Research Center (NSRRC) and the sunsetting Swine Somatic Cell Genome Editing Consortium
Large Animal Testing Center. The Resource Section will have a significant impact on the overall Swine SCGE
Center’s ability to accurately assess new technologies and further facilitate the ability to use genome editing in
therapeutic circumstances.

## Key facts

- **NIH application ID:** 10928247
- **Project number:** 5U42OD035738-02
- **Recipient organization:** UNIVERSITY OF MISSOURI-COLUMBIA
- **Principal Investigator:** RANDALL S PRATHER
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $270,601
- **Award type:** 5
- **Project period:** 2023-09-12 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10928247

## Citation

> US National Institutes of Health, RePORTER application 10928247, Resource: Swine Somatic Cell Gene Editing Testing Center (5U42OD035738-02). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10928247. Licensed CC0.

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