ABSTRACT – ADMINISTRATIVE CORE The purpose of the Administrative Core is to provide leadership, oversight, coordination, and general administrative support for all activities of the University of North Carolina (UNC) Core Center for Clinical Research (CCCR). The Administrative Core’s specific goal is to maximize the scientific integrity and dissemination of the CCCR’s work, which is focused on optimizing clinical research and clinical trials that will advance clinical care and public health efforts targeted toward individuals with Rheumatic and Musculoskeletal Diseases (RMDs) with a focus on osteoarthritis (OA). This Core will facilitate the delivery of novel, innovative, and exciting services provided by our Methodology and Phenotyping and Precision Medicine Resource Cores to our research community at UNC, throughout the state of North Carolina (NC) and beyond. Our research community also includes members of the Internal (IAB) and External (EAB) Advisory Boards, and specific collaborations with the NC Translational and Clinical Sciences Institute (NC TraCS), home to our Clinical and Translational Science Award (CTSA). This CCCR will build on the strong success of the current CCCR housed at the Thurston Arthritis Research Center (TARC). The CCCR will leverage the Osteoarthritis Action Alliance (OAAA), a coalition of more than 150 organizations committed to elevating OA as a national health priority, and Communication Officers from OAAA and TARC. The Administrative Core’s purpose will be accomplished through the following specific aims: 1) Provide leadership and vision to guide the CCCR in its focus on optimizing clinical research and clinical trials to advance clinical care and public health efforts targeted toward all people with OA and other RMDs within the mission of NIAMS; 2) Provide oversight and coordination for the Methodology and Resource Cores, ensuring their success in meeting their goals; support enrichment programs for trainees including pilot and feasibility grants; and evaluate metrics across all CCCR programs; 3) Continue to coordinate and integrate the services of our valued and unique Stakeholder Advisory Board (SAB) across Cores and to maintain communication links among the SAB, Executive Committee, Methodology Core, Resource Core, IAB, EAB, the CCCR Research Community, and the other NIAMS funded CCCRs; 4) Provide structure and oversight of communication and outreach efforts between the CCCR and the extensive ongoing TARC research activities, OAAA, NC TraCS, and other UNC Schools, Departments, Centers, and Programs, as well as with public and private organizations at the state, national, and international levels.