# The UNC Core Center for Clinical Research: Methodology Core

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $234,925

## Abstract

ABSTRACT – METHODOLOGY CORE
Significant gaps persist in the understanding of disease onset, progression, and optimal treatment approaches
for osteoarthritis (OA) and other rheumatic and musculoskeletal diseases (RMDs). There is a critical need for
high quality, innovative and efficient clinical RMD studies that will successfully address these key
research questions and meaningfully impact the lives of patients with these conditions. The
Methodology Core of University of North Carolina Core Center for Clinical Research is uniquely equipped to
provide a comprehensive suite of state-of-the-art resources to optimize clinical RMD studies locally, nationally,
and internationally. Our Methodology Core includes researchers with expertise in in biostatistics, epidemiology,
data science, clinical trials, dissemination and implementation, study logistics, imaging, biomarkers, social
determinants of health, intervention development, clinical aspects of RMDs, and education. We have a long,
successful track record of designing and conducting seminal clinical RMD studies, developing junior
investigators into independent researchers, fostering national/international collaborations, delivering
methodological training to RMD communities, leading national and international work groups, and influencing
public policy. Building and expanding on our proven processes and established infrastructure, the Methodology
Core will continue to serve the clinical RMD research community by achieving three specific aims. First, we will
provide comprehensive, rigorous multidisciplinary methodological services that support and advance clinical
RMD research, emphasizing development and application of innovative statistical and data science
methodologies. This will be achieved through a series of ongoing activities including Advisory, Brainstorming
and Consultative (ABC) group sessions and individual consultations. Second, we will support the activities of
our Phenotyping and Precision Medicine Resource Core, particularly through collaboration on advanced
statistical analyses and data science methodologies. Third, we will develop and deliver state-of-the-art
educational materials and training that prepare researchers, both locally and nationally/internationally, to
conduct high quality, innovative clinical RMD studies and analyses. This will be achieved through conference
symposia, webinars, and intensive training and mentoring of early career investigators. The Methodology
Core, in collaboration with the Resource Core, will leverage a wealth of scientific expertise and
experience to significantly advance clinical RMD research. We are poised to support our research
community in making major impacts in the lives of individuals with RMDs.

## Key facts

- **NIH application ID:** 10928433
- **Project number:** 2P30AR072580-06
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** TODD A SCHWARTZ
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $234,925
- **Award type:** 2
- **Project period:** 2019-09-04 → 2029-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10928433

## Citation

> US National Institutes of Health, RePORTER application 10928433, The UNC Core Center for Clinical Research: Methodology Core (2P30AR072580-06). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10928433. Licensed CC0.

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