# Constructing the subjective value of food in Anorexia Nervosa

> **NIH NIH R01** · UNIVERSITY OF CHICAGO · 2024 · $566,465

## Abstract

Project Summary
Anorexia Nervosa (AN) is a serious eating disorder with a mortality rate among the highest of any psychiatric
illness. Identifying modifiable targets for the development of novel AN interventions is crucial because leading
treatments achieve remission rates of less than 50%, and relapse is common. One aspect of AN that likely
contributes to poor long-term outcomes is maladaptive food choice, i.e., the persistent and stereotyped choice
of low-calorie, low-fat foods. Food choice requires individuals to construct the subjective value of foods from a
number of attributes. Yet, despite the centrality of food choice in AN, little is known about how people with AN
construct the subjective values placed on foods, leading to maladaptive food-choice behavior. The overall goal
of this research is to elucidate the cognitive and neural mechanisms that contribute to subjective food valuation
in AN. Leveraging fMRI, eyetracking, and computational models that have advanced understanding of
decision-making in healthy individuals, we propose two studies to examine: (1) how individuals with AN
combine across attributes to construct subjective value for food; (2) how the cognitive and neural mechanisms
that contribute to valuation and food choice differ between individuals with AN and healthy controls (HC); and
(3) how the value construction process can be biased to influence food choice. Study 1 will examine choices,
reaction times, eyetracking, and fMRI measures obtained while individuals with AN (n=75) and HC (n=75)
perform a novel multi-attribute decision task during which they will rate food items on attributes such as
healthiness, tastiness, and savoriness, and then choose between 2 “meals” each composed of three different
food items from different categories. We hypothesize that compared to HC, individuals with AN will base their
subjective valuation of meal options largely on healthiness-related attributes and attend more to healthiness-
related attributes. We also hypothesize that representations of healthiness in patterns of BOLD activity in the
orbitofrontal cortex (OFC) will be more related to food choice in AN than HC. Study 2 will use cue-approach
training (CAT), which has shown that the mere association of a cue and an action (a button press) with an
image leads to enduring preference changes and attentional biases in favor of cued items. We will combine CAT
with multi-attribute choices used in Study 1 and cue highly tasty foods for all participants. We hypothesize that
attentional bias following CAT will alter the value construction process in AN (but not HCs) by increasing the
value of tastiness attributes, and that healthiness representations in patterns of BOLD activity in AN OFC will
be no more related to meal choices than tastiness representations. This research is the first effort to identify
mechanisms underlying subjective food valuation in AN, and test whether value construction can be altered to
normalize food-choice behavio...

## Key facts

- **NIH application ID:** 10929296
- **Project number:** 5R01MH132792-02
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Akram Bakkour
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $566,465
- **Award type:** 5
- **Project period:** 2023-09-14 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10929296

## Citation

> US National Institutes of Health, RePORTER application 10929296, Constructing the subjective value of food in Anorexia Nervosa (5R01MH132792-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10929296. Licensed CC0.

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