# Gene Delivery

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA BERKELEY · 2024 · $197,518

## Abstract

Project Summary Gene Delivery Core
Vision research has benefited enormously by the advent of gene delivery technologies, aimed at
understanding the development, physiology, and pathology of the visual system, and in
developing strategies for treating ocular disease. Especially important have been advances in
AAV based gene therapy, directed evolution of new AAV capsid variants, restoration of retinal
responses in degenerative diseases by optogenetic proteins, and CRISPR/Cas9 based gene
editing technology for editing endogenous genes in the eye and the brain. Over the past two and
half decades, the Gene Delivery Core (GDM) has played an essential role in helping our Vision
Science researchers employ these technologies, fostering collaboration among labs, and
attracting new labs into pursuing questions that are relevant for vision science. Our goal in the
next funding period is to continue providing this essential service to Core investigators, their
labs, and the larger Vision Science community at UC Berkeley. The aims of the Core are 1)
Design and produce viral vectors for Vision Science researchers, 2) Introduce new gene delivery
technologies to Vision Science researchers, 3) Assist UC Berkeley Vision Science researchers in
generating transgenic animal models.

## Key facts

- **NIH application ID:** 10929317
- **Project number:** 5P30EY003176-42
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** Xiaohua Gong
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $197,518
- **Award type:** 5
- **Project period:** 1997-08-01 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10929317

## Citation

> US National Institutes of Health, RePORTER application 10929317, Gene Delivery (5P30EY003176-42). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10929317. Licensed CC0.

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