# Statistics Core

> **NIH NIH U19** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $1,396,123

## Abstract

PROJECT SUMMARY – Statistics Core
The purpose of the Statistics Core (SC) is to support and advance the Clinical significance of INciDEntal white
matter lEsions on MRI in a Diverse population with cognitive complaints (INDEED) by developing innovative
tools for data collection and management, harmonizing data across clinical sites, developing deep learning and
biomechanical neuroimaging quantification of white matter injury, performing statistical analysis for
investigators, and sharing data through a research portal with internal and external investigators. The SC will
undertake 5 specific aims to fulfill this purpose: 1) develop a data management system that will integrate data
across the cores, provide a reporting system for tracking of study progress and describing characteristics of
participants, and support a resource portal for data sharing and data interrogation; 2) provide harmonization of
neuroimaging data to enable pooling of data across sites; 3) develop methods to better capture the spectrum
of white matter injury and its biomechanical consequences; 4) test key hypotheses posed in the Overall section
of the application; and 5) develop and validate risk scores. The SC brings together a qualified team with
expertise in data management, MRI harmonization, development of imaging metrics and numerical models of
biological systems, analysis of risk factors associated with cognitive decline and incident dementia, and
development of risk scores to accomplish these aims. Innovations include a database capable of dynamic
reporting and querying of the database, cutting-edge approaches to MRI harmonization, deep learning and
multivariate approaches to better characterize white matter injury, and development of multi-modal risk scores.
The SC will integrate data from the Repository Core, provide tracking information for the Recruitment and
Retention Core, and serve on committees within the Administrative Core. The work of the Core will support the
overall goal of predicting the impact of progressive WM injury on cognition using a precision medicine
approach in a large and diverse clinical population.

## Key facts

- **NIH application ID:** 10929344
- **Project number:** 5U19NS120384-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Kumar B. Rajan
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,396,123
- **Award type:** 5
- **Project period:** 2020-09-30 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10929344

## Citation

> US National Institutes of Health, RePORTER application 10929344, Statistics Core (5U19NS120384-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10929344. Licensed CC0.

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