ABSTRACT - ADMINISTRATIVE CORE The goal of Advance Clinical and Translational Research (Advance-CTR) is to bridge the gaps between the worlds of clinical and basic science by developing a multi-institutional, clinical translational research infrastructure that beneficially impacts clinical practice and health care policy in Rhode Island. We will leverage Rhode Island’s educational institutions, streamlined clinical environment, and IDeA sponsored research mentoring programs and state of the art research infrastructure to enhance clinical translational research by supporting the research, training, management, oversight, and coordination processes needed to transform the clinical and translational research environment in our participating institutions. The Administrative Core is responsible for the leadership and management structure for effectively managing, coordinating and supervising the Advance-CTR. The leadership structure builds upon the Culture of Collaboration demonstrated by the numerous examples of inter-institutional high impact awards that have been received and that support this IDeA-CTR. The structure ensures representation by working across a statewide consortium of universities, hospitals, government agencies, non- profits, industry partners, and the Departments of Health to impact the health of Rhode Islanders. Within Brown University, Advance-CTR collaborations extend across the Division of Biology and Medicine, the Alpert Medical School, the Program in Biology, the School of Public Health, the School of Engineering, and other Institutes and Centers. At the University of Rhode Island, we impact the Colleges of Pharmacy, Nursing, and Environment & Life Sciences. Through strategic partnerships with the Rhode Island Quality Institute and access to the All Payor Claims Database, we are able to evaluate the health care of all of Rhode Islanders through truly population based epidemiological studies, population phenotyping and clinical surveys. This IDeA-CTR proposal has the following Specific Aims: 1) Provide the organizational structure, leadership, governance, and advisory support to develop, maintain, and enhance Advance-CTR Core activities in support of clinical and translational research. 2) Enable the development, coordination, and implementation of strategic initiatives and manage the business, financial, communication, and evaluation functions necessary to ensure efficient operations and to foster growth and the long-term sustainability of Advance-CTR. 3) Serve as a source for developing written policies and procedures necessary for effective organization governance and long-term sustainability of Advance-CTR and retention of clinical research investigators.