PROJECT SUMMARY - ADMINISTRATIVE CORE The Administrative Core (AC) will provide a structure to facilitate effective and integrative interactions between the TCORS team. The AC will ensure all programmatic activities focus on achieving the overall goal of the Center – using our integrative theme, “Flipping the Script”: Using the Industry's Nicotine Playbook to Maximize Public Health, to understand how industry nicotine manipulations in electronic cigarettes (ECs) and oral nicotine pouches (ONPs) are impacting product appeal, addictiveness, use patterns, and toxicity. The resulting data will inform effective product standards and marketing regulations on nicotine manipulations with the intent to dissuade young people, including non-users, from using ECs and ONPs, but still provide a satisfying and less harmful alternative for adult tobacco users (smokers and smokeless tobacco users) who completely switch to these products. The AC will foster and promote the goals of each component (cores and projects) by providing scientific direction, administrative support, oversight, and integration of Center activities to ensure operational efficiency. The Specific Aims of the AC are to: 1) Provide overall research direction and center oversight by setting the research agenda focused on determining how manipulation of nicotine and aspects of product packaging, impact product appeal, addictiveness, and toxicity; 2) Promote communication and integration within the Center as well as promote interaction between other funded TCORS, the Center for Coordination of Analysis, Science, Enhancement, and Logistics (CASEL), the Center for Rapid Surveillance of Tobacco (CRST), and the FDA and NIH staff; 3) Coordinate and organize committee structure and communications, and ensure operational efficiency for all projects, pilot studies and cores of the center; and 4) Foster dissemination of tobacco regulatory research findings, including data sharing. For this last aim, the Translational Tobacco Policy Team (TPT) will have oversight and provide critical input ensuring research data has translational impact to inform effective tobacco policy. The AC will ensure that all components of the Center work seamlessly together to accomplish the overall and component-specific goals of this Center. The resulting data from our center projects will inform effective product standards and marketing regulations on nicotine dimensions that dissuade young non-users from using ECs and ONPs but still provide a satisfying and less harmful alternative for adult tobacco users.