PROJECT SUMMARY / ABSTRACT Disparities in the incidence and prognosis of cancer in the United States are widespread, well documented, and persistent. Still, there remains a critical need to thoughtfully examine and address the myriad factors contributing to these disparities. For the past 20 years, we have conducted a Training Program in cancer prevention and survival (15 years as an R25, 5 years as a T32), with an emphasis on the roles of nutrition, lifestyle factors, and genetics in cancer. We have had substantial success in trainee degree completion, recruitment of trainees from underrepresented backgrounds, and placement of pre- and postdoctoral fellows in research-related positions. With this renewal, we are proposing to reframe the focus of our Program to support trainees in the pursuit of research on cancer health disparities and the social determinants of health that drive those disparities. The objective of this Program is to advance opportunities for trainees, particularly those from underrepresented backgrounds, in research for the reduction and elimination of cancer health disparities. In pursuit of this objective, we will provide trainees with 1) formal coursework in cancer epidemiology, social determinants of health, and cancer disparities, 2) experiences in epidemiologic research, with an emphasis on cancer epidemiology and health disparities research, and 3) skills and practice in grant writing, disseminating scientific findings, and developing a long-term career plan. Together, these activities will support our trainees in preparing them for careers in impactful research. We propose to train 4 pre- and 3 postdoctoral trainees each year. Formal coursework and degrees will be based in the University of Washington (UW) Department of Epidemiology. Trainees will gain practical experience in epidemiologic research within the UW Department of Epidemiology and at the Fred Hutchinson Cancer Center. Trainees will have access to considerable resources and 26 exceptional faculty mentors at these two partner institutions. New faculty mentors have been added to provide expertise in health disparities and social determinants of health, along with several junior faculty co- mentors with innovative research directly relevant to the goals of this Training Program. This Training Program will be led by two Program Directors, both of whom hold joint appointments at the two participating institutions and share a history of collaborative research in studies of cancer disparities: Dr. Amanda Phipps is an Associate Professor and Associate Chair at the UW Department of Epidemiology; Dr. Christopher Li is a Professor, the Vice President for Faculty Affairs and Inclusion, and Associate Director of the Office of Diversity, Equity, and Inclusion at the Fred Hutchinson Cancer Center. Through the support of Drs. Phipps and Li, the oversight of knowledgeable internal and external advisors, and the guidance of outstanding Program faculty mentors, trainees who com...