ABSTRACT - ADMINISTRATIVE CORE The Administrative Core of the Mayo Clinic American Joint Replacement Research Collaborative (AJRR-C) provides support for the scientific and administrative work of the Methodology and Resource Cores and expand the TJA research community with the overarching goal to accelerate innovative, high quality, high impact, and interdisciplinary clinical research in TJA. The centralized research governance at Mayo Clinic enables the Administrative Core to efficiently manage the administration of the AJRR-C. We leverage the unique expertise, data and infrastructure resources of the Mayo Clinic as well as the national registry American Joint Replacement Registry (AJRR) as the Resource Core. The Executive Management Team focus on integration of the AJRR-C within the institution, ensures the quality and efficiency of AJRR-C activities through administrative and scientific oversight, communication and outreach efforts with professional societies and other stakeholders, and continuous improvement using robust evaluation metrics. The Executive Management Team receives strategic input from the External Advisory Committee composed of surgeons who are leaders in TJA clinical research, methodology experts and partners from research databases. The Specific Aims of the Administrative Core are: (1) To provide leadership and the overall organizational infrastructure to AJRR-C, strengthening its role as a national methodology hub for clinical research in TJA, (2) To stimulate and oversee regional and national collaborations, (3) To oversee and ensure the quality and efficiency of AJRR-C activities including pilot and feasibility studies and the fellowship program, and (4) To evaluate key metrics for success related to all AJRR-C activities.