Abstract – Data Core The primary purpose of the Data core is to collect, store, coordinate, and transfer all data, metadata, and analysis strategies generated within the U19 center (the INTERCEPT pain center) to the U24 DCIC and the HEAL Platform. The Data core will conduct multiple inter-disciplinary genomic and statistical analyses to study and integrate the multi-level omics data obtained from the three individual component projects of the INTERCEPT Center. The INTERCEPT Center projects involve extensive data management and complex analyses. Such analyses require organized and simultaneous consideration of data from different component projects, and demand robust and innovative integrated analysis methodology. The Data core provides the required data management and coordination function, as well as the bioinformatic expertise and innovative integrated genomic analysis to enable the success of the INTERCEPT Center. The main objective of the Data core is to serve as a backbone support resource for experimental design refinement, data quality control, management, integration, analyses, and interpretation, and serve as a central hub to foster data and information exchange and collaboration between individual projects and cores in the INTERCEPT Center. Built upon the Core members’ close and long-time collaboration and extensive experience in multi-omics data analyses, this Data core will provide essential services through the following specific aims: 1) Provide central data storage, management, and information security services to all researchers within the U19 Center and ensure the timely submission of data and data analyses to the HEAL Platform. 2) Integrated multi-omic characterization of the peripheral nervous system to identify spatially resolved cells, genes, and pathways associated with pain conditions.