ABSTRACT The purpose of the Administrative Core is to provide the leadership and administrative management for the proposed Pacific Center for Genome Research (PCGR) aimed at capitalizing on the infrastructure at the University of Hawaii at Manoa (UHM) and the racial/ethnic diversity of its catchment area to conduct genomic research addressing the racial/ethnic differences in disease risks and outcomes that exist in Hawai`i and the Pacific. The Administrative Core will build upon a number of institutional resources, both administrative and scientific, to foster the implementation and coordination of the research in this U54. This Core will also closely coordinate the U54 resource-building and career-development activities with those implemented by UHM, so greater efficiency is achieved at the institutional level. Thus, this Core serves major administrative and integrative functions for the grant. The U54 will rely on an Internal Advisory Committee (IAC), consisting of key senior scientists on genome research, to receive input on research opportunities and to facilitate coordination with potentially synergistic local initiatives. The program will also benefit from the input of a Community Advisory Board (CAB) composed of community leaders and patient advocates with experience in disease disparities and/or survivorship, and who will advise on the responsiveness of our activities to community needs and expectations. Program evaluation will heavily rely on the input of an External Advisory Board (EAB) composed of outside investigators who are leaders in genome research. Specific Aim 1 will be to organize, integrate, and provide administrative management of all Projects and Cores. Specific Aim 2 will be to provide project management oversight to track milestones and timelines of the individual Projects and Cores. Specific Aim 3 will be to facilitate collaborations. The Administrative Core will play an essential role in supporting the research program proposed in the U54. We believe that the skills and experience of Core Co-Directors and the proven approaches described in this section will provide both the foundation and the building blocks to achieve our goals.