Abstract: The overarching goal of the Ohio State University (OSU) Center for Clinical and Translational Science affiliated K12 program is to develop a cadre of well-trained, diverse, early-stage faculty investigators through individualized training to engage fully, succeed, and lead in clinical translational research and science (CTR/CTS). The program is open to eligible early career faculty members at the Ohio State University (OSU) and Nationwide Children’s Hospital (NCH). To accomplish this, we propose the following Specific Objectives (S.O.): S.O.1) Provide training to foster the development and long-term success of diverse, early career faculty engaged in clinical and translational research; S.O.2) Provide mentorship training and monitor progress for scholars, mentors, and mentor-mentee dyads; S.O.3). Support the development of skills for scholars to lead in translational science; and S.O.4) Conduct ongoing evaluation of program and scholar outcomes for continuous improvement. Highlights of our comprehensive, impactful, and innovative programmatic training elements include: development of monitored individual training plans (IDP); structured communication and grant writing preparation; leadership skill development; understanding and thriving in a team science environment; training in responsible conduct of research; training in research ethics; training to promote diversity and inclusiveness in research teams and participants; research design and data interpretation; and training in rigor and reproducibility in the conduct of research. Program elements will be opened to other institutional and individual K scholars at OSU and NCH. Training in Diversity, Equity, Inclusion and Accessibility is provided to both K12 mentors and mentors. Four early career K12 scholars will be trained with two-year appointments (2 per year) supported by the K12, followed by institutional support to continue a third year of K12 training. Scholar success will be defined based on research productivity (particularly independent research funding in CTR/CTS) and progression in the characteristics of a translational scientist. Scholars will be monitored during the K12 based on their IDPs with a dedicated team of senior mentors engaged and funded in CTR/CTS and experienced in mentoring early-stage faculty. The K12 Program will regularly track progress of of its Specific Objective by evaluating career advancement as CTR/CTS scientists (independent research funding, publications, academic promotion) and participation and leadership in clinical and translational research and clinical and translational science. A RE- AIM and Logic Model framework will be used for programmatic evaluation and programmatic adaptation. The OSU campus research environment with our urban, suburban, and rural patient communities, and the ability to look at questions across the lifespan through our partnership with NCH provides a range of opportunities to train future leaders in clinical and translat...